Journal article
Pancuronium improves the neuromuscular transmission defect of human organophosphate intoxication
Neurology, Vol.40(8), pp.1275-1277
08/1990
DOI: 10.1212/WNL.40.8.1275
PMID: 2166248
Abstract
Two patients with acute severe organophosphate intoxication showed (1) single evoked compound muscle action potentials (CMAP) with repetitive discharges and (2) prominent decremental responses of CMAP with 20 and 50 Hz supramaximal nerve stimulation. Following the intravenous injection of single small doses of pancuronium, marked improvement in these abnormalities occurred and persisted for several hours. We postulate that the physiologic improvement following low-dose pancuronium results from blockade of acetylcholine receptors, especially those located on the terminal axon responsible for antidromic backfiring.
Details
- Title: Subtitle
- Pancuronium improves the neuromuscular transmission defect of human organophosphate intoxication
- Creators
- R Besser - Department of Neurology, University of Mainz, West GermanyT VogtL Gutmann
- Resource Type
- Journal article
- Publication Details
- Neurology, Vol.40(8), pp.1275-1277
- Publisher
- United States
- DOI
- 10.1212/WNL.40.8.1275
- PMID
- 2166248
- ISSN
- 0028-3878
- eISSN
- 1526-632X
- Language
- English
- Date published
- 08/1990
- Academic Unit
- Neurology
- Record Identifier
- 9984020764202771
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