Pandemic 2009 influenza A (H1N1) in 71 critically ill pregnant women in California

Sascha R Ellington; Laura K Hartman; Meileen Acosta; Miguel Martinez-Romo; Lewis Rubinson; Denise J Jamieson; Janice Louie

doi:10.1016/j.ajog.2011.02.038

Back

Pandemic 2009 influenza A (H1N1) in 71 critically ill pregnant women in California

Journal article

Peer reviewed

Pandemic 2009 influenza A (H1N1) in 71 critically ill pregnant women in California

Sascha R Ellington, Laura K Hartman, Meileen Acosta, Miguel Martinez-Romo, Lewis Rubinson, Denise J Jamieson and Janice Louie

American journal of obstetrics and gynecology, Vol.204(6 Suppl 1), pp.S21-S30

06/01/2011

DOI: 10.1016/j.ajog.2011.02.038

PMID: 21514554

View Online

Abstract

We sought to describe the characteristics and clinical management of 71 critically ill pregnant women with pandemic 2009 influenza A (H1N1 [2009 H1N1]). This was a retrospective case series from April 23, 2009, through March 18, 2010, of pregnant women with 2009 H1N1 in intensive care units in California. Among 71 critically ill pregnant women with 2009 H1N1, rapid decline in clinical status was noted with a median duration of 1 day from hospital admission to intensive care unit admission. Adverse events were common, and included sepsis (n = 26), hematologic disorder (n = 17), and pneumothorax (n = 15). Of 42 women requiring invasive ventilation, 15 (36%) died. In total, 23 women required rescue therapies for severe gas exchange abnormalities. Adverse events were significantly associated with survival (P = .0003). Women who received early antiviral treatment were significantly more likely to survive (relative risk, 1.43; 95% confidence interval, 1.18-1.75). Critically ill pregnant women with 2009 H1N1 declined rapidly and developed frequent adverse events including death.

Adolescent

Adult

California - epidemiology

Critical Care

Critical Illness

Female

Humans

Influenza A Virus, H1N1 Subtype

Influenza, Human - epidemiology

Influenza, Human - therapy

Pandemics

Pregnancy

Pregnancy Complications, Infectious - epidemiology

Pregnancy Complications, Infectious - therapy

Retrospective Studies

Treatment Outcome

Young Adult

Details

Title: Subtitle: Pandemic 2009 influenza A (H1N1) in 71 critically ill pregnant women in California
Creators: Sascha R Ellington - Centers for Disease Control and Prevention
Laura K Hartman - National Center on Birth Defects and Developmental Disabilities
Meileen Acosta - California Department of Public Health
Miguel Martinez-Romo - California Department of Public Health
Lewis Rubinson - Office of Readiness and Response
Denise J Jamieson - National Center for Chronic Disease Prevention and Health Promotion
Janice Louie - California Department of Public Health
Resource Type: Journal article
Publication Details: American journal of obstetrics and gynecology, Vol.204(6 Suppl 1), pp.S21-S30
DOI: 10.1016/j.ajog.2011.02.038
PMID: 21514554
ISSN: 0002-9378
eISSN: 1097-6868
Language: English
Date published: 06/01/2011
Academic Unit: Obstetrics and Gynecology; VPMA - Administration
Record Identifier: 9984446433402771

Metrics

9 Record Views

31 Times Cited - Web of Science