Papillomavirus E6 oncoproteins

Scott B Vande Pol; Aloysius J Klingelhutz

doi:10.1016/j.virol.2013.04.026

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Journal article

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Peer reviewed

Papillomavirus E6 oncoproteins

Scott B Vande Pol and Aloysius J Klingelhutz

Virology (New York, N.Y.), Vol.445(1-2), pp.115-137

10/2013

DOI: 10.1016/j.virol.2013.04.026

PMCID: PMC3783570

PMID: 23711382

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Abstract

Papillomaviruses induce benign and malignant epithelial tumors, and the viral E6 oncoprotein is essential for full transformation. E6 contributes to transformation by associating with cellular proteins, docking on specific acidic LXXLL peptide motifs found on these proteins. This review examines insights from recent studies of human and animal E6 proteins that determine the three-dimensional structure of E6 when bound to acidic LXXLL peptides. The structure of E6 is related to recent advances in the purification and identification of E6 associated protein complexes. These E6 protein-complexes, together with other proteins that bind to E6, alter a broad array of biological outcomes including modulation of cell survival, cellular transcription, host cell differentiation, growth factor dependence, DNA damage responses, and cell cycle progression.

Paxillin - metabolism

Papillomaviridae - metabolism

Humans

Ubiquitin-Protein Ligases - metabolism

Uterine Cervical Neoplasms - pathology

Papillomaviridae - genetics

Protein Folding

Amino Acid Motifs

Papillomavirus Infections - pathology

Ubiquitination

Animals

Papillomavirus Infections - metabolism

Protein Binding

Uterine Cervical Neoplasms - virology

Female

Oncogene Proteins, Viral - genetics

Oncogene Proteins, Viral - metabolism

Details

Title: Subtitle: Papillomavirus E6 oncoproteins
Creators: Scott B Vande Pol - Department of Pathology, University of Virginia, Charlottesville, VA 22901, USA. Electronic address: vandepol@virginia.edu
Aloysius J Klingelhutz
Resource Type: Journal article
Publication Details: Virology (New York, N.Y.), Vol.445(1-2), pp.115-137
DOI: 10.1016/j.virol.2013.04.026
PMID: 23711382
PMCID: PMC3783570
NLM abbreviation: Virology
ISSN: 0042-6822
eISSN: 1096-0341
Publisher: United States
Grant note: AG027388 / NIA NIH HHS R01 CA120352 / NCI NIH HHS CA120352 / NCI NIH HHS R01 AG027388 / NIA NIH HHS P30 CA044579 / NCI NIH HHS R21 DE019953 / NIDCR NIH HHS DE019953 / NIDCR NIH HHS CA08093 / NCI NIH HHS R01 CA134737 / NCI NIH HHS
Language: English
Date published: 10/2013
Academic Unit: Microbiology and Immunology; Radiation Oncology
Record Identifier: 9984001216302771

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