Journal article
Paracrine Role of Prostanoids in Activation of Arterial Baroreceptors: An Overview
Clinical and experimental hypertension (1993), Vol.A13(5), pp.817-824
1991
DOI: 10.3109/10641969109042085
PMID: 1773513
Abstract
Baroreceptors located in carotid sinuses and aortic arch are activated with increases in arterial pressure. The increased afferent nerve activity triggers reflex adjustments that buffer the rise in pressure. Mechanical deformation of baroreceptor nerve endings is considered the primary mechanism of receptor activation. Recent studies in our laboratory have demonstrated that prostanoids, most likely released from endothelial cells during stretch, contribute - as paracrine factors - to the activation of baroreceptors. Exposure of the isolated carotid sinus in anesthetized rabbits to prostacyclin (PGI2) or arachidonic acid increases baroreceptor sensitivity whereas inhibition of endogenous formation of prostanoids with indomethacin or aspirin decreases sensitivity. Baroreceptor sensitivity is also decreased after endothelial denudation and restored after adding PGI2 back to the denuded sinus suggesting that endothelium is the source of prostanoids that sensitize baroreceptors. Pathologic states such as chronic hypertension and atherosclerosis are associated with both endothelial cell dysfunction and decreased baroreceptor sensitivity. The endothelial cell dysfunction and impairment of prostanoid formation contribute to the decreased baroreceptor sensitivity in these diseases.
Details
- Title: Subtitle
- Paracrine Role of Prostanoids in Activation of Arterial Baroreceptors: An Overview
- Creators
- Mark W Chapleau - 1Department of Internal Medicine and Physiology & Biophysics and The Cardiovascular Center, University of Iowa College of Medicine, Iowa City, Iowa, 52242George Hajduczok - 1Department of Internal Medicine and Physiology & Biophysics and The Cardiovascular Center, University of Iowa College of Medicine, Iowa City, Iowa, 52242Francois M Abboud - 1Department of Internal Medicine and Physiology & Biophysics and The Cardiovascular Center, University of Iowa College of Medicine, Iowa City, Iowa, 52242
- Resource Type
- Journal article
- Publication Details
- Clinical and experimental hypertension (1993), Vol.A13(5), pp.817-824
- Publisher
- Informa UK Ltd
- DOI
- 10.3109/10641969109042085
- PMID
- 1773513
- ISSN
- 1064-1963
- eISSN
- 1525-6006
- Language
- English
- Date published
- 1991
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025565102771
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