Paracrine WNT5A signaling in healthy and neoplastic mammary tissue

David Kusner; Nicholas Borcherding; Weizhou Zhang

doi:10.1080/23723556.2015.1040145

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Paracrine WNT5A signaling in healthy and neoplastic mammary tissue

Journal article

Open access

Paracrine WNT5A signaling in healthy and neoplastic mammary tissue

David Kusner, Nicholas Borcherding and Weizhou Zhang

Molecular & cellular oncology, Vol.3(1), pp.e1040145-e1040145

01/02/2016

DOI: 10.1080/23723556.2015.1040145

PMCID: PMC4845198

PMID: 27308558

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https://doi.org/10.1080/23723556.2015.1040145View

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Abstract

Paracrine signaling between mammary epithelial cells has long been appreciated. Recently, we found that Wnt5a, a novel noncanonical Wnt ligand of luminal origin, counteracts canonical Wnt signaling in basal mammary epithelial cells through a paracrine pathway, inhibits the expansion of Erbb2-induced tumor-initiating cells, and suppresses tumor incidence and metastasis.

Breast Cancer

WNT5A signaling

Noncanonical WNT

mammary development

Details

Title: Subtitle: Paracrine WNT5A signaling in healthy and neoplastic mammary tissue
Creators: David Kusner - University of Iowa, Internal Medicine
Nicholas Borcherding - Molecular and Cellular Biology Program, Carver College of Medicine, University of Iowa
Weizhou Zhang - Immunology Program, Carver College of Medicine, University of Iowa
Resource Type: Journal article
Publication Details: Molecular & cellular oncology, Vol.3(1), pp.e1040145-e1040145
Publisher: Taylor & Francis
DOI: 10.1080/23723556.2015.1040145
PMID: 27308558
PMCID: PMC4845198
ISSN: 2372-3556
eISSN: 2372-3556
Language: English
Date published: 01/02/2016
Academic Unit: Dermatology; Radiation Oncology; Internal Medicine
Record Identifier: 9984083877902771

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