Paradigm Shift in Early Detection: Lung Cancer Screening to Comprehensive CT Screening

James L Mulshine; Bruce Pyenson; Cheryl Healton; Carolyn Aldige; Riccardo S. Avila; Torsten Blum; Matthew Cham; Harry J de Koning; Sean B Fain; John K Field; Raja Flores; Maryellen L. Giger; Ilya Gipp; Frederic W Grannis; Jan Willem C Gratama; Ella A Kazerooni; Karen Kelly; Harriet L Lancaster; Luis Montuenga; Kyle J Myers; Morteza Naghavi; Raymond Osarogiagbon; Ugo Pastorino; Anthony P Reeves; Albert Rizzo; Sheila Ross; Victoria Schneider; Luis M Seijo; Dorith Shaham; Mario Silva; Robert Smith; Emanuela Taioli; Kevin ten Haaf; Carlijn M van der Aalst; Lucia Viola; Jens Vogel-Claussen; Anna N.H. Walstra; Ning Wu; Pan-Chyr Yang; Rowena Yip; David F. Yankelevitz; Claudia I. Henschke; Matthijs Oudkerk

doi:10.1016/j.ejca.2025.115264

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Paradigm Shift in Early Detection: Lung Cancer Screening to Comprehensive CT Screening

Journal article

Peer reviewed

Paradigm Shift in Early Detection: Lung Cancer Screening to Comprehensive CT Screening

James L Mulshine, Bruce Pyenson, Cheryl Healton, Carolyn Aldige, Riccardo S. Avila, Torsten Blum, Matthew Cham, Harry J de Koning, Sean B Fain, John K Field, …

European journal of cancer (1990), Vol.218, 115264

03/11/2025

DOI: 10.1016/j.ejca.2025.115264

PMID: 39904127

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https://pure.eur.nl/en/publications/4f32a670-197b-40c9-bcc1-f3a47e367277View

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Abstract

Large-scale lung cancer screening implementation combined with improvements in early detection techniques for three major tobacco-related diseases presents a rare opportunity to markedly improve population health outcomes for millions of people. Chest CT enables routine detection of early lung cancer as well as characterizing coronary calcium and detecting early emphysema in the course of lung cancer screening. Integrated preventive care centered on comprehensive chest CT screening has the potential to bring large benefits across co-morbid diseases with a common etiology. The current one-disease/ silo paradigm of medical practice is an obstacle to maximizing chest CT screening’s benefits. The large potential for improved health outcomes across the world demands careful public health, quality assurance, and health policy considerations. A systematic analysis of imaging and health data from ongoing chest CT screening could accelerate this paradigm shift through sustained optimization of screening detection, quantitation and management for the three most lethal tobacco-related co-morbidities. To coordinate this effort to advance progress with implementing the full benefit of comprehensive chest CT screening, a new multi- disciplinary professional and advocacy consortium has been developed to foster collaboration to realize the future of multi-disease chest CT screening. •Lung cancer screening is being implemented worldwide in tobacco-exposed individuals•Asymptomatic cases of co-morbid cardiovascular and pulmonary disease are detected•These three chest diseases are major global drivers of premature death•Finding much new thoracic disease in screens is stimulating a paradigm shift•Cross-cutting preemptive interventions for disease cohorts is a strategic opportunity

Lung Cancer

chest CT scan

chronic obstructive pulmonary disease

coronary artery disease

emphysema

lung cancer screening

quantitative imaging

Details

Title: Subtitle: Paradigm Shift in Early Detection: Lung Cancer Screening to Comprehensive CT Screening
Creators: James L Mulshine - Rush University
Bruce Pyenson - Milliman (United States)
Cheryl Healton - New York University
Carolyn Aldige - Prevent Cancer Foundation
Riccardo S. Avila - Accumetra, LLC
Torsten Blum - Helios Klinikum Emil von Behring
Matthew Cham - University of Washington
Harry J de Koning - Erasmus MC
Sean B Fain - University of Iowa
John K Field - University of Liverpool
Raja Flores - Mount Sinai Health System
Maryellen L. Giger - University of Chicago
Ilya Gipp - General Electric (United States)
Frederic W Grannis - City Of Hope National Medical Center
Jan Willem C Gratama - Gelre Hospitals
Ella A Kazerooni - Michigan Medicine
Karen Kelly - International Association for the Study of Lung Cancer
Harriet L Lancaster - University Medical Center Groningen
Luis Montuenga - Universidad de Navarra
Kyle J Myers - Institute for Advanced Study
Morteza Naghavi - HeartLung AI Technologies, Houston, TX, USA
Raymond Osarogiagbon - Baptist Cancer Center
Ugo Pastorino - Fondazione IRCCS Istituto Nazionale dei Tumori
Anthony P Reeves - Cornell University
Albert Rizzo - American Lung Association
Sheila Ross - I-ELCAP Board, Annapolis, MD, USA
Victoria Schneider - Siemens Healthineers (Germany)
Luis M Seijo - Clinica Universidad de Navarra
Dorith Shaham - Hadassah Medical Center
Mario Silva - University of Parma
Robert Smith - American Cancer Society
Emanuela Taioli - Mount Sinai Health System
Kevin ten Haaf - Erasmus MC
Carlijn M van der Aalst - Erasmus MC
Lucia Viola - Fundación Neumológica Colombiana
Jens Vogel-Claussen - Medizinische Hochschule Hannover
Anna N.H. Walstra - Institute for Diagnostic Accuracy, Groningen, NL
Ning Wu - Chinese Academy of Medical Sciences & Peking Union Medical College
Pan-Chyr Yang - National Taiwan University
Rowena Yip - Mount Sinai Health System
David F. Yankelevitz - Mount Sinai Health System
Claudia I. Henschke - Mount Sinai Health System
Matthijs Oudkerk - Institute for Diagnostic Accuracy, Groningen, NL
Resource Type: Journal article
Publication Details: European journal of cancer (1990), Vol.218, 115264
DOI: 10.1016/j.ejca.2025.115264
PMID: 39904127
NLM abbreviation: Eur J Cancer
ISSN: 0959-8049
eISSN: 1879-0852
Publisher: Elsevier Ltd
Language: English
Electronic publication date: 01/31/2025
Date published: 03/11/2025
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
Record Identifier: 9984786280102771

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