Journal article
Paradoxical dose- and time-dependent regulation of superoxide dismutase and antioxidant capacity by vitamin E in rat
Clinica chimica acta, Vol.365(1), pp.153-159
2006
DOI: 10.1016/j.cca.2005.08.008
PMID: 16183047
Abstract
Previous data about the regulation of SOD activity as the key part of the endogenous antioxidant system by vitamin E is conflicting.
We investigated the effect of different nontoxic doses of vitamin E on erythrocyte SOD activity and plasma total antioxidant capacity in rats, receiving 0 (control group), 100, 300 and 600 mg vitamin E
/
kilogram of body weight intramuscularly twice a week over 6-weeks.
We observed a linear increase in SOD activity in the first dosing group, which was significant (
p
<
0.05) after 6th week compared to the control level. There was an increase in SOD activity at the end of 2nd and significant increase after 4th weeks, which was followed by a significant decrease at the end of 6th week in the second dosing group. In the third dosing group, there was a significant increase at the end of 2nd week and a significant decrease at the end of 4th and 6th weeks in the SOD activity. The changes in plasma antioxidant capacity were parallel to that of SOD activity with a significant and strong degree of correlation in the 4th and 6th weeks (
r
=
0.7 and
r
=
0.8, respectively). Serum levels of Vitamin E also increased in a time- and dose-dependent manner; the highest level was achieved in the 600 mg/kg dosing group after 6 weeks.
Non-toxic doses of vitamin E at some levels can up-regulate SOD activity, but cumulative effect of the same doses can lead to attenuation of SOD activity and hence antioxidant defense.
Details
- Title: Subtitle
- Paradoxical dose- and time-dependent regulation of superoxide dismutase and antioxidant capacity by vitamin E in rat
- Creators
- Abolfazl Golestani - Tehran University of Medical SciencesRoghieh Rastegar - Tehran University of Medical SciencesAhmad Shariftabrizi - Tehran University of Medical SciencesShahnaz Khaghani - Tehran University of Medical SciencesSeyed Mehdi Payabvash - Department of Pharmacology, Tehran University of Medical Sciences, Tehran, IranAmirali H. Salmasi - Tehran University of Medical SciencesAhmad R. Dehpour - Tehran University of Medical SciencesParvin Pasalar - Tehran University of Medical Sciences
- Resource Type
- Journal article
- Publication Details
- Clinica chimica acta, Vol.365(1), pp.153-159
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.cca.2005.08.008
- PMID
- 16183047
- ISSN
- 0009-8981
- eISSN
- 1873-3492
- Language
- English
- Date published
- 2006
- Academic Unit
- Radiology
- Record Identifier
- 9984318718502771
Metrics
13 Record Views