Journal article
Parallel Instabilities of Long-Term Potentiation, Place Cells, and Learning Caused by Decreased Protein Kinase A Activity
The Journal of neuroscience, Vol.20(21), pp.8096-8102
11/01/2000
DOI: 10.1523/JNEUROSCI.20-21-08096.2000
PMCID: PMC6772748
PMID: 11050131
Abstract
To further elucidate the links among synaptic plasticity, hippocampal place cells, and spatial memory, place cells were recorded from wild-type mice and transgenic “R(AB)” mice with reduced forebrain protein kinase A (PKA) activity after introduction into a novel environment. Place cells in both strains were similar during the first exposure and were equally stable for recording sessions separated by 1 hr. Place cell stability in wild-type mice was unchanged for sessions separated by 24 hr but was reduced in R(AB) mice over the longer interval. This stability pattern parallels both the reduced late-phase long-term potentiation in hippocampal slices from R(AB) mice and the amnesia for context fear conditioning seen in R(AB) mice 24 but not 1 hr after training. The similar time courses of synaptic, network, and behavioral instability suggest that the genetic reduction of PKA activity is responsible for the defects at each level and support the idea that hippocampal synaptic plasticity is important in spatial memory.
Details
- Title: Subtitle
- Parallel Instabilities of Long-Term Potentiation, Place Cells, and Learning Caused by Decreased Protein Kinase A Activity
- Creators
- Alexander RotenbergTed AbelRobert D HawkinsEric R KandelRobert U Muller
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.20(21), pp.8096-8102
- Publisher
- Society for Neuroscience
- DOI
- 10.1523/JNEUROSCI.20-21-08096.2000
- PMID
- 11050131
- PMCID
- PMC6772748
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Language
- English
- Date published
- 11/01/2000
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065828502771
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