Journal article
Parallel evolution of polymer chemistry and immunology: Integrating mechanistic biology with materials design
Advanced drug delivery reviews, Vol.156, pp.65-79
01/01/2020
DOI: 10.1016/j.addr.2020.06.021
PMID: 32589903
Abstract
To develop new therapeutics involves the interaction of multiple disciplines to yield safe, functional devices and formulations. Regardless of drug function and potency, administration with controlled timing, dosing, and targeting is required to properly treat or regulate health and disease. Delivery approaches can be optimized through advances in materials science, clinical testing, and basic biology and immunology. Presently, laboratories focused on developing these technologies are composed of, or collaborate with, chemists, biologists, materials scientists, engineers, and physicians to understand the way our body interacts with drug delivery devices, and how to synthesize new, rationally designed materials to improve targeted and controlled drug delivery. In this review, we discuss both device-based and micro/nanoparticle-based materials in the clinic, our biologic understanding of how our immune system interacts with these materials, how this diverse set of immune cells has become a target and variable in drug delivery design, and new directions in polymer chemistry to address these interactions and further our advances in medical therapeutics. (C) 2020 Elsevier B.V. All rights reserved.
Details
- Title: Subtitle
- Parallel evolution of polymer chemistry and immunology: Integrating mechanistic biology with materials design
- Creators
- Kaitlyn Sadtler - National Institute of Biomedical Imaging and BioengineeringJoe Collins - Massachusetts Institute of TechnologyJames D. Byrne - Massachusetts Institute of TechnologyRobert Langer - Massachusetts Institute of Technology
- Resource Type
- Journal article
- Publication Details
- Advanced drug delivery reviews, Vol.156, pp.65-79
- DOI
- 10.1016/j.addr.2020.06.021
- PMID
- 32589903
- NLM abbreviation
- Adv Drug Deliv Rev
- ISSN
- 0169-409X
- eISSN
- 1872-8294
- Publisher
- Elsevier
- Number of pages
- 15
- Grant note
- EB000244; DE013023; EB027717-01A1 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 1F32EB025688-01A1 / Ruth L. Kirschstein NRSA post-doctoral fellowship from NIBIB Prostate Cancer Foundation Young Investigator Award
- Language
- English
- Date published
- 01/01/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiation Oncology
- Record Identifier
- 9984274755302771
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