Journal article
Parallel faster-X evolution of gene expression and protein sequences in Drosophila: beyond differences in expression properties and protein interactions
PloS one, Vol.10(3), pp.e0116829-e0116829
2015
DOI: 10.1371/journal.pone.0116829
PMCID: PMC4366066
PMID: 25789611
Abstract
Population genetics models predict that the X (or Z) chromosome will evolve at faster rates than the autosomes in XY (or ZW) systems. Studies of molecular evolution using large datasets in multiple species have provided evidence supporting this faster-X effect in protein-coding sequences and, more recently, in transcriptomes. However, X-linked and autosomal genes differ significantly in important properties besides hemizygosity in males, including gene expression levels, tissue specificity in gene expression, and the number of interactions in which they are involved (i.e., protein-protein or DNA-protein interactions). Most important, these properties are known to correlate with rates of evolution, which raises the question of whether differences between the X chromosome and autosomes in gene properties, rather than hemizygosity, are sufficient to explain faster-X evolution. Here I investigate this possibility using whole genome sequences and transcriptomes of Drosophila yakuba and D. santomea and show that this is not the case. Additional factors are needed to account for faster-X evolution of both gene expression and protein-coding sequences beyond differences in gene properties, likely a higher incidence of positive selection in combination with the accumulation of weakly deleterious mutations.
Details
- Title: Subtitle
- Parallel faster-X evolution of gene expression and protein sequences in Drosophila: beyond differences in expression properties and protein interactions
- Creators
- Ana Llopart - Department of Biology, The University of Iowa, Iowa City, Iowa, United States of America; Interdisciplinary Graduate Program in Genetics, The University of Iowa, Iowa City, Iowa, United States of America
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.10(3), pp.e0116829-e0116829
- DOI
- 10.1371/journal.pone.0116829
- PMID
- 25789611
- PMCID
- PMC4366066
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Publisher
- United States
- Language
- English
- Date published
- 2015
- Academic Unit
- Biology
- Record Identifier
- 9983991995902771
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