Paraneoplastic pemphigus, cicatricial conjunctivitis, and acanthosis nigricans with pachydermatoglyphy in a patient with bronchogenic squamous cell carcinoma

Sheridan Lam; M S Stone; J A Goeken; Stephen J Massicotte; Ann Coleman Smith; Robert Folberg; Jay H Krachmer

doi:10.1016/S0161-6420(92)32030-5

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Paraneoplastic pemphigus, cicatricial conjunctivitis, and acanthosis nigricans with pachydermatoglyphy in a patient with bronchogenic squamous cell carcinoma

Journal article

Peer reviewed

Paraneoplastic pemphigus, cicatricial conjunctivitis, and acanthosis nigricans with pachydermatoglyphy in a patient with bronchogenic squamous cell carcinoma

Sheridan Lam, M S Stone, J A Goeken, Stephen J Massicotte, Ann Coleman Smith, Robert Folberg and Jay H Krachmer

Ophthalmology (Rochester, Minn.), Vol.99(1), pp.108-113

01/1992

DOI: 10.1016/S0161-6420(92)32030-5

PMID: 1741121

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Abstract

A 77-year-old man with chronic conjunctivitis, acanthosis nigricans with pachydermatoglyphy, and pemphigus-like mucocutaneous lesions was found to have a well-differentiated bronchogenic squamous cell carcinoma. Histopathologic and immunofluorescence studies confirmed the diagnosis of paraneoplastic pemphigus. Skin lesions resolved with oral prednisone and azathioprine therapy, but the conjunctivitis and mucous membrane erosions persisted. The conjunctiva later became scarred with foreshortening of the fornices and development of symblepharon. External beam irradiation arrested the growth of the tumor but did not have any effect on the diseased conjunctiva and other mucous membranes. This case demonstrates that cicatrizing conjunctivitis with bullous mucocutaneous lesions may be a clinical sign associated with an occult neoplasm.

Azathioprine - therapeutic use

Carcinoma, Squamous Cell - pathology

Humans

Lung Neoplasms - radiotherapy

Acanthosis Nigricans - complications

Lung Neoplasms - pathology

Male

Osteoarthropathy, Primary Hypertrophic - pathology

Pemphigus - drug therapy

Skin Diseases - pathology

Carcinoma, Squamous Cell - radiotherapy

Osteoarthropathy, Primary Hypertrophic - complications

Carcinoma, Bronchogenic - pathology

Conjunctivitis - pathology

Cicatrix - drug therapy

Acanthosis Nigricans - pathology

Paraneoplastic Syndromes - pathology

Pemphigus - pathology

Fluorescent Antibody Technique

Paraneoplastic Syndromes - drug therapy

Aged

Carcinoma, Bronchogenic - radiotherapy

Cicatrix - pathology

Chronic Disease

Microscopy, Fluorescence

Prednisone - therapeutic use

Details

Title: Subtitle: Paraneoplastic pemphigus, cicatricial conjunctivitis, and acanthosis nigricans with pachydermatoglyphy in a patient with bronchogenic squamous cell carcinoma
Creators: Sheridan Lam - Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City 52242
M S Stone
J A Goeken
Stephen J Massicotte
Ann Coleman Smith
Robert Folberg
Jay H Krachmer
Resource Type: Journal article
Publication Details: Ophthalmology (Rochester, Minn.), Vol.99(1), pp.108-113
Publisher: United States
DOI: 10.1016/S0161-6420(92)32030-5
PMID: 1741121
ISSN: 0161-6420
eISSN: 1549-4713
Language: English
Date published: 01/1992
Academic Unit: Dermatology; Pathology
Record Identifier: 9984025667802771

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