Journal article
Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity
The American journal of tropical medicine and hygiene, Vol.48(6), pp.739-741
1993
DOI: 10.4269/ajtmh.1993.48.739
PMID: 8333566
Abstract
This report compares the use of the lactate dehydrogenase (pLDH) assay with 3H-hypoxanthine incorporation and Giemsa microscopy for the evaluation of anti-malaria drug inhibition of the growth of P. falciparum in vitro. The inhibition profiles and IC50 determinations of the pLDH assay were directly comparable to those determined by the radioactive uptake and microscopic methods. Furthermore, the pLDH culture sensitivity assay is reproducible, easily interpreted, rapid and inexpensive to perform, suggesting field applicability.
Details
- Title: Subtitle
- Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity
- Creators
- M. T Makler - Veterans Health AdministrationJ. M Ries - Veterans affairs medical cent., lab. res. serv., Portland OR, United StatesJ. A Williams - Veterans affairs medical cent., lab. res. serv., Portland OR, United StatesJ. E Bancroft - Veterans affairs medical cent., lab. res. serv., Portland OR, United StatesR. C Piper - Veterans affairs medical cent., lab. res. serv., Portland OR, United StatesB. L Gibbins - Veterans affairs medical cent., lab. res. serv., Portland OR, United StatesD. J Hinrichs - Veterans affairs medical cent., lab. res. serv., Portland OR, United States
- Resource Type
- Journal article
- Publication Details
- The American journal of tropical medicine and hygiene, Vol.48(6), pp.739-741
- Publisher
- Allen Press
- DOI
- 10.4269/ajtmh.1993.48.739
- PMID
- 8333566
- ISSN
- 0002-9637
- eISSN
- 1476-1645
- Language
- English
- Date published
- 1993
- Academic Unit
- Molecular Physiology and Biophysics; Medicine Administration; Internal Medicine
- Record Identifier
- 9984297611902771
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