Parcellation of Human and Monkey Core Auditory Cortex with fMRI Pattern Classification and Objective Detection of Tonotopic Gradient Reversals

Marc Schönwiesner; Peter Dechent; Dirk Voit; Christopher I Petkov; Katrin Krumbholz

doi:10.1093/cercor/bhu124

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Parcellation of Human and Monkey Core Auditory Cortex with fMRI Pattern Classification and Objective Detection of Tonotopic Gradient Reversals

Journal article

Open access

Peer reviewed

Parcellation of Human and Monkey Core Auditory Cortex with fMRI Pattern Classification and Objective Detection of Tonotopic Gradient Reversals

Marc Schönwiesner, Peter Dechent, Dirk Voit, Christopher I Petkov and Katrin Krumbholz

Cerebral cortex (New York, N.Y. 1991), Vol.25(10), pp.3278-3289

10/2015

DOI: 10.1093/cercor/bhu124

PMCID: PMC4585487

PMID: 24904067

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Abstract

Auditory cortex (AC) contains several primary-like, or "core," fields, which receive thalamic input and project to non-primary "belt" fields. In humans, the organization and layout of core and belt auditory fields are still poorly understood, and most auditory neuroimaging studies rely on macroanatomical criteria, rather than functional localization of distinct fields. A myeloarchitectonic method has been suggested recently for distinguishing between core and belt fields in humans (Dick F, Tierney AT, Lutti A, Josephs O, Sereno MI, Weiskopf N. 2012. In vivo functional and myeloarchitectonic mapping of human primary auditory areas. J Neurosci. 32:16095-16105). We propose a marker for core AC based directly on functional magnetic resonance imaging (fMRI) data and pattern classification. We show that a portion of AC in Heschl's gyrus classifies sound frequency more accurately than other regions in AC. Using fMRI data from macaques, we validate that the region where frequency classification performance is significantly above chance overlaps core auditory fields, predominantly A1. Within this region, we measure tonotopic gradients and estimate the locations of the human homologues of the core auditory subfields A1 and R. Our results provide a functional rather than anatomical localizer for core AC. We posit that inter-individual variability in the layout of core AC might explain disagreements between results from previous neuroimaging and cytological studies.

Acoustic Stimulation

Adult

Animals

Auditory Cortex - physiology

Auditory Perception - physiology

Brain Mapping - methods

Female

Humans

Image Processing, Computer-Assisted - methods

Macaca

Magnetic Resonance Imaging - methods

Male

Signal Processing, Computer-Assisted

Species Specificity

Details

Title: Subtitle: Parcellation of Human and Monkey Core Auditory Cortex with fMRI Pattern Classification and Objective Detection of Tonotopic Gradient Reversals
Creators: Marc Schönwiesner - Montreal Neurological Institute and Hospital
Peter Dechent - University of Göttingen
Dirk Voit - Max Planck Institute for Biophysical Chemistry
Christopher I Petkov - University of Newcastle Australia
Katrin Krumbholz - MRC Institute of Hearing Research
Resource Type: Journal article
Publication Details: Cerebral cortex (New York, N.Y. 1991), Vol.25(10), pp.3278-3289
DOI: 10.1093/cercor/bhu124
PMID: 24904067
PMCID: PMC4585487
NLM abbreviation: Cereb Cortex
ISSN: 1047-3211
eISSN: 1460-2199
Grant note: NC/K000608/1 / National Centre for the Replacement, Refinement and Reduction of Animals in Research MC_U135097128 / Medical Research Council 102961/Z/13/Z / Wellcome Trust 102961 / Wellcome Trust
Language: English
Date published: 10/2015
Academic Unit: Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984360005902771

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