Journal article
Parental Age and Severity of Non-Syndromic Orofacial Clefts: Relationship with De Novo Mutations
Nigerian Dental Journal, Vol.32(3), pp.57-64
10/17/2024
DOI: 10.61172/k2m6rt36
Abstract
Background: This study investigates the relationship between paternal and maternal age, and the severity of orofacial clefts and the presence of de novo mutations in children. Methods: This was a retrospective study of individuals who were diagnosed with non-syndromic cleft lip and/or palate (CL/P) and their unaffected parents, from 2012 to 2019. We obtained data from the AfriCRAN project database for Nigerians with non-syndromic orofacial clefts. These individuals were recruited at the Oral and Maxillofacial Surgery Clinic, Lagos University Teaching Hospital, Lagos. Results: There was no statistically significant association between type of CL ± P and parental age in young fathers (p = 0.93). When older fathers were considered, the percentage of complete (more severe) CL ± P cases increased, especially when they were married to older mothers, and this was statistically significant (p = 0.036). In older fathers, the risk of CL ± P in their offspring was increased (OR: 2.66, CI: 1.04-6.80), and there was also an increased risk of developing right-sided CL ± P (OR: 1.61, CI: 1.0-2.59). There was a reduced risk of isolated clefts of the soft palate in younger fathers (OR: 0.36, CI: 0.07–1.71), but the risk increased when considering complete types (more severe) of isolated clefts of the hard and soft palates (OR: 1.63, CI: 0.7–1.7). There was an increase in de novo mutation in children as the difference between paternal and maternal age increased. Conclusion: The study showed that a higher risk of CL ± P and de novo mutations in children is associated with increased parental age.
Details
- Title: Subtitle
- Parental Age and Severity of Non-Syndromic Orofacial Clefts: Relationship with De Novo Mutations
- Creators
- Olawale Adamson - University of LagosAbimbola Oladugba - University of NigeriaAzeez Alade - University of IowaWaheed Awotoye - University of IowaTamara Busch - University of IowaMary LI - University of IowaAzeez Fashina - University of LagosJoy Olotu - University of Port HarcourtVeronica Sule - University of IowaOlutayo JamesMobolanle Ogunlewe - University of LagosWasiu AdeyemoAzeez Butali - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Nigerian Dental Journal, Vol.32(3), pp.57-64
- DOI
- 10.61172/k2m6rt36
- ISSN
- 0189-1006
- Language
- English
- Date published
- 10/17/2024
- Academic Unit
- Oral Pathology, Radiology and Medicine; Stead Family Department of Pediatrics; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984738389202771
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