Journal article
Parental Remission from Alcohol Use Disorder and Offspring Alcohol Use Initiation, AUD, and Remission in a High-Risk Family Sample
Journal of studies on alcohol and drugs, Vol.86(6), pp.906-916
11/2025
DOI: 10.15288/jsad.24-00268
PMCID: PMC12576940
PMID: 39913279
Abstract
We investigate offspring alcohol use outcomes as a function of unremitted and remitted parental alcohol use disorder (AUD).
Self-report data of participants in the Collaborative Study on the Genetics of Alcoholism (COGA) were used. Offspring (n=2244, mean age 16.3 at baseline, 26.9 years at follow-up, 50.8% female) were linked to parent data. Time-varying associations of parental AUD and remission with offspring age at first drink, years from first drink to AUD onset, and years from AUD onset to first remission were tested in Cox models adjusted for polygenic risk for problematic alcohol use (PGSPAU). Analyses were stratified by genetically inferred continental groups of European (EA, 65.9%) and African (AA, 34.1%) Americans due to sociocultural factors that can contribute to differences in alcohol use and problems.
In EA, maternal remission was associated with increased risk for offspring AUD; neither maternal nor paternal remission was associated with other outcomes. In AA, maternal and paternal remission were associated with increased likelihood of early drinking; the association with maternal drinking varied as a function of whom offspring lived with during adolescence. Paternal, but not maternal, remission was associated with heightened risk for AUD onset. Parental status had no association with offspring remission in EA or AA.
Evidence that parental remission can help mitigate the risk associated with parental AUD and increase likelihood of remission in affected offspring was limited and mixed based on continental group and sex. These nuanced outcomes highlight the complex interplay of parental AUD status and offspring's alcohol-related behaviors.
Details
- Title: Subtitle
- Parental Remission from Alcohol Use Disorder and Offspring Alcohol Use Initiation, AUD, and Remission in a High-Risk Family Sample
- Creators
- Vivia V McCutcheon - Washington University in St. LouisSally I-Chun Kuo - Rutgers, The State University of New JerseyRebecca L Smith - Virginia Commonwealth UniversityRebecca Tillman - Washington University in St. LouisDongbing Lai - Indiana University – Purdue University IndianapolisMeredith W Francis - Virginia Commonwealth UniversityJessica L Bourdon - University of RichmondChella Kamarajan - SUNY Downstate Health Sciences UniversityGrace Chan - University of IowaWeipeng Kuang - SUNY Downstate Health Sciences UniversityChristina E Garasky - Washington University in St. LouisCarolyn E Sartor - Washington University in St. LouisVictor Hesselbrock - University of ConnecticutSamuel Kuperman - University of IowaMartin H Plawecki - Indiana University – Purdue University IndianapolisArpana Agrawal - Washington University in St. LouisEmma C Johnson - Washington University in St. LouisMarc A Schuckit - University of California San DiegoJessica E Salvatore - Rutgers, The State University of New JerseyKathleen K Bucholz - Washington University in St. Louis
- Resource Type
- Journal article
- Publication Details
- Journal of studies on alcohol and drugs, Vol.86(6), pp.906-916
- DOI
- 10.15288/jsad.24-00268
- PMID
- 39913279
- PMCID
- PMC12576940
- NLM abbreviation
- J Stud Alcohol Drugs
- ISSN
- 1938-4114
- eISSN
- 1938-4114
- Publisher
- Alcohol Research Documentation, Inc.
- Language
- English
- Electronic publication date
- 02/06/2025
- Date published
- 11/2025
- Academic Unit
- Psychiatry
- Record Identifier
- 9984786442202771
Metrics
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