Parental occupational pesticide exposure and nonsyndromic orofacial clefts

Jonathan Suhl; Paul A Romitti; Carissa Rocheleau; Yanyan Cao; Trudy L Burns; Kristin Conway; Erin M Bell; Patricia Stewart; Peter Langlois; Natl Birth Defects Prevention

doi:10.1080/15459624.2018.1484127

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Parental occupational pesticide exposure and nonsyndromic orofacial clefts

Journal article

Open access

Peer reviewed

Parental occupational pesticide exposure and nonsyndromic orofacial clefts

Jonathan Suhl, Paul A Romitti, Carissa Rocheleau, Yanyan Cao, Trudy L Burns, Kristin Conway, Erin M Bell, Patricia Stewart, Peter Langlois and Natl Birth Defects Prevention

Journal of Occupational and Environmental Hygiene, Vol.15(9), pp.641-653

09/02/2018

DOI: 10.1080/15459624.2018.1484127

PMCID: PMC7099602

PMID: 29993348

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https://www.ncbi.nlm.nih.gov/pmc/articles/7099602View

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Abstract

Nonsyndromic orofacial clefts are common birth defects. Reported risks for orofacial clefts associated with parental occupational pesticide exposure are mixed. To examine the role of parental pesticide exposure in orofacial cleft development in offspring, this study compared population-based case-control data for parental occupational exposures to insecticides, herbicides, and fungicides, alone or in combinations, during maternal (1 month before through 3 months after conception) and paternal (3 months before through 3 months after conception) critical exposure periods between orofacial cleft cases and unaffected controls. Multivariable logistic regression was used to estimate odds ratios, adjusted for relevant covariables, and 95% confidence intervals for any (yes, no) and cumulative (none, low [<median exposure level in controls], high [≥median exposure level in controls]) occupational pesticide exposures and cleft lip ± cleft palate and cleft palate. Associations for cleft lip ± cleft palate tended to be near unity for maternal or paternal occupational pesticide exposures, except for low paternal exposure to any pesticide, which produced a statistically significant inverse association with this subtype. Associations for cleft palate tended to be near unity for maternal exposures and mostly positive, but non-significant, for paternal exposures; a significant positive association was observed between paternal low exposure to insecticide + herbicide + fungicide and cleft palate. Combined parental exposure produced non-significant associations near or below unity for all orofacial cleft cases combined and cleft lip ± cleft palate and positive, but non-significant, associations for cleft palate. This study observed associations mostly near unity between maternal occupational pesticide exposure and orofacial clefts. Associations for paternal occupational pesticide exposures were mostly near or below unity for cleft lip ± cleft palate, and mostly positive for cleft palate. However, due to the limitations of this study, these subtype-specific results should be interpreted cautiously. Future research examining parental occupational pesticide exposure and orofacial clefts should attempt to improve exposure assessment and increase sample size to better facilitate risk estimation.

Pesticides

Pregnancy

Herbicides

cleft palate

Cleft lip

insecticides

Details

Title: Subtitle: Parental occupational pesticide exposure and nonsyndromic orofacial clefts
Creators: Jonathan Suhl - Department of Epidemiology, College of Public Health, The University of Iowa
Paul A Romitti - Department of Epidemiology, College of Public Health, The University of Iowa
Carissa Rocheleau - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention
Yanyan Cao - Department of Epidemiology, College of Public Health, The University of Iowa
Trudy L Burns - Department of Epidemiology, College of Public Health, The University of Iowa
Kristin Conway - Department of Epidemiology, College of Public Health, The University of Iowa
Erin M Bell - University at Albany, State University of New York
Patricia Stewart - Stewart Exposure Assessments, LLC
Peter Langlois - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services
Natl Birth Defects Prevention
Resource Type: Journal article
Publication Details: Journal of Occupational and Environmental Hygiene, Vol.15(9), pp.641-653
DOI: 10.1080/15459624.2018.1484127
PMID: 29993348
PMCID: PMC7099602
NLM abbreviation: J Occup Environ Hyg
ISSN: 1545-9624
eISSN: 1545-9632
Publisher: Taylor & Francis
Grant note: U01DD001035 / Centers for Disease Control and Prevention
Language: English
Date published: 09/02/2018
Academic Unit: Epidemiology; Biostatistics; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9983995045502771

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