Parental smoking during pregnancy and the risk of gestational diabetes in the daughter

Wei Bao; Karin B Michels; Deirdre K Tobias; Shanshan Li; Jorge E Chavarro; Audrey J Gaskins; Allan A Vaag; Frank B Hu; Cuilin Zhang

doi:10.1093/ije/dyv334

Back

Parental smoking during pregnancy and the risk of gestational diabetes in the daughter

Journal article

Open access

Peer reviewed

Parental smoking during pregnancy and the risk of gestational diabetes in the daughter

Wei Bao, Karin B Michels, Deirdre K Tobias, Shanshan Li, Jorge E Chavarro, Audrey J Gaskins, Allan A Vaag, Frank B Hu and Cuilin Zhang

International journal of epidemiology, Vol.45(1), pp.160-169

02/2016

DOI: 10.1093/ije/dyv334

PMCID: PMC4881834

PMID: 26748845

Files and links (1)

url

https://doi.org/10.1093/ije/dyv334View

Published (Version of record) Open Access

Abstract

Fetal exposure to parental smoking may have long-term impact on the development of disease in adulthood. We examined the association of parental smoking during pregnancy with risk of gestational diabetes mellitus (GDM) in the daughter. We included 15,665 singleton pregnancies from 10,152 women in the Nurses' Health Study II cohort whose mothers participated in the Nurses' Mothers' Cohort Study. Data on maternal and paternal smoking during pregnancy and associated covariates were recalled by the mothers. GDM diagnosis was self-reported by the daughters and was validated by medical record review in a previous study. We used log-binomial models with generalized estimating equations to estimate relative risks (RRs) and 95% confidence intervals (CIs). We observed a positive association between maternal heavy smoking during pregnancy and risk of GDM in the daughter. The multivariable-adjusted RRs (95% CIs) of GDM among women whose mothers did not smoke during pregnancy, continued smoking 1-14, 15-24, and ≥ 25 cigarettes/day were 1.00 (reference), 1.05 (0.81-1.35), 1.27 (0.95-1.70) and 1.98 (1.18-3.30), respectively (P for trend = 0.01). Further adjustment for the women's perinatal variables, adult-life characteristics and body mass index during various periods of life modestly attenuated the association. No association was observed between paternal smoking during the pregnancy period and risk of GDM in the daughter. Maternal heavy smoking (≥ 25 cigarettes/day) during pregnancy was associated with higher risk of gestational diabetes in the daughter. Further studies are warranted to confirm our findings and to elucidate the underlying mechanisms.

Multivariate Analysis

Prospective Studies

Prenatal Exposure Delayed Effects - epidemiology

Humans

Risk Factors

Diabetes, Gestational - epidemiology

Mothers

Pregnancy

Young Adult

Regression Analysis

Smoking - epidemiology

Adult

Female

Surveys and Questionnaires

Diabetes, Gestational - etiology

Details

Title: Subtitle: Parental smoking during pregnancy and the risk of gestational diabetes in the daughter
Creators: Wei Bao - Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD, USA
Karin B Michels - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Department of Obstetrics, Gynecology and Reproductive Biology
Deirdre K Tobias - Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA and
Shanshan Li - Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD, USA
Jorge E Chavarro - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA and
Audrey J Gaskins - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA and
Allan A Vaag - Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark
Frank B Hu - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA and
Cuilin Zhang - Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD, USA, zhangcu@mail.nih.gov
Resource Type: Journal article
Publication Details: International journal of epidemiology, Vol.45(1), pp.160-169
Publisher: England
DOI: 10.1093/ije/dyv334
PMID: 26748845
PMCID: PMC4881834
ISSN: 1464-3685
eISSN: 1464-3685
Grant note: P30 DK46200 / NIDDK NIH HHS Intramural NIH HHS T32-DK007703‐16 / NIDDK NIH HHS N02-RC-17027 / CCR NIH HHS P30 DK046200 / NIDDK NIH HHS CA50385 / NCI NIH HHS HHSN275201000020C / PHS HHS DK58845 / NIDDK NIH HHS P0 263 MQ 411027 / PHS HHS CA176726 / NCI NIH HHS K01 DK103720 / NIDDK NIH HHS
Language: English
Date published: 02/2016
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9983995129602771

Metrics

23 Record Views

33 Times Cited - Web of Science

See more details