Parenting Moderates a Genetic Vulnerability Factor in Longitudinal Increases in Youths' Substance Use

Gene H Brody; Steven R. H Beach; Robert A Philibert; Yi-fu Chen; Man-Kit Lei; Velma McBride Murry; Anita C Brown

doi:10.1037/a0012996

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Parenting Moderates a Genetic Vulnerability Factor in Longitudinal Increases in Youths' Substance Use

Journal article

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Parenting Moderates a Genetic Vulnerability Factor in Longitudinal Increases in Youths' Substance Use

Gene H Brody, Steven R. H Beach, Robert A Philibert, Yi-fu Chen, Man-Kit Lei, Velma McBride Murry and Anita C Brown

Journal of consulting and clinical psychology, Vol.77(1), pp.1-11

02/2009

DOI: 10.1037/a0012996

PMCID: PMC2868377

PMID: 19170449

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https://www.ncbi.nlm.nih.gov/pmc/articles/2868377View

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Abstract

The authors used a longitudinal, prospective design to investigate a moderation effect in the association between a genetic vulnerability factor, a variable nucleotide repeat polymorphism in the promoter region of 5HTT (5-HTTLPR), and increases in youths' substance use. The primary study hypothesis predicted that involved-supportive parenting would attenuate the link between the 5-HTTLPR polymorphism and longitudinal increases in substance use. African American youths residing in rural Georgia (N = 253, mean age = 11.5 years) provided 4 waves of data on their own substance use; the mothers of the youths provided data on their own parenting practices. Genetic data were obtained from youths via saliva samples. Latent growth curve modeling indicated that 5-HTTLPR status (presence of 1 or 2 copies of the s allele) was linked with increases in substance use over time; however, this association was greatly reduced when youths received high levels of involved-supportive parenting. This study demonstrates that parenting processes have the potential to ameliorate genetic risk.

substance use

adolescence

genetics

parenting

African American

Details

Title: Subtitle: Parenting Moderates a Genetic Vulnerability Factor in Longitudinal Increases in Youths' Substance Use
Creators: Gene H Brody - Center for Family Research, University of Georgia
Steven R. H Beach - Institute for Behavioral Research, University of Georgia
Robert A Philibert - Department of Psychiatry, University of Iowa
Yi-fu Chen - Center for Family Research, University of Georgia
Man-Kit Lei - Center for Family Research, University of Georgia
Velma McBride Murry - Center for Family Research, University of Georgia
Anita C Brown - Center for Family Research, University of Georgia
Contributors: Annette M La Greca (Editor)
Resource Type: Journal article
Publication Details: Journal of consulting and clinical psychology, Vol.77(1), pp.1-11
DOI: 10.1037/a0012996
PMID: 19170449
PMCID: PMC2868377
NLM abbreviation: J Consult Clin Psychol
ISSN: 0022-006X
eISSN: 1939-2117
Publisher: American Psychological Association
Grant note: DOI: 10.13039/100000027, name: National Institute on Alcohol Abuse and Alcoholism; DOI: 10.13039/100000026, name: National Institute on Drug Abuse; DOI: 10.13039/100000025, name: National Institute of Mental Health
Language: English
Date published: 02/2009
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003955502771

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