Parenting, Socioeconomic Status Risk, and Later Young Adult Health: Exploration of Opposing Indirect Effects via DNA Methylation

Steven R H Beach; Man-Kit Lei; Gene H Brody; Sangjin Kim; Allen W Barton; Meesha V Dogan; Robert A Philibert

doi:10.1111/cdev.12486

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Parenting, Socioeconomic Status Risk, and Later Young Adult Health: Exploration of Opposing Indirect Effects via DNA Methylation

Journal article

Peer reviewed

Parenting, Socioeconomic Status Risk, and Later Young Adult Health: Exploration of Opposing Indirect Effects via DNA Methylation

Steven R H Beach, Man-Kit Lei, Gene H Brody, Sangjin Kim, Allen W Barton, Meesha V Dogan and Robert A Philibert

Child development, Vol.87(1), pp.111-121

01/2016

DOI: 10.1111/cdev.12486

PMCID: PMC4733891

PMID: 26822447

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Abstract

A sample of 398 African American youth, residing in rural counties with high poverty and unemployment, were followed from ages 11 to 19. Protective parenting was associated with better health, whereas elevated socioeconomic status (SES) risk was associated with poorer health at age 19. Genome-wide epigenetic variation assessed in young adulthood (age 19), was associated with both SES risk and protective parenting. Three categories of genes were identified whose methylation was associated with parenting, SES risk, and young adult health. Methylation was a significant mediator of the impact of parenting and SES risk on young adult health. Variation in mononuclear white blood cell types was also examined and controlled, showing that it did not account for observed effects of parenting and SES risk on health.

Parenting

Poverty

Follow-Up Studies

Humans

African Americans - genetics

Male

Risk

DNA Methylation - genetics

Social Class

Young Adult

Epigenesis, Genetic - genetics

Rural Population

Adolescent

Adult

Female

Health Status

Child

Details

Title: Subtitle: Parenting, Socioeconomic Status Risk, and Later Young Adult Health: Exploration of Opposing Indirect Effects via DNA Methylation
Creators: Steven R H Beach - University of Georgia
Man-Kit Lei - University of Georgia
Gene H Brody - University of Georgia
Sangjin Kim - University of Georgia
Allen W Barton - University of Georgia
Meesha V Dogan - University of Iowa
Robert A Philibert - University of Iowa
Resource Type: Journal article
Publication Details: Child development, Vol.87(1), pp.111-121
DOI: 10.1111/cdev.12486
PMID: 26822447
PMCID: PMC4733891
NLM abbreviation: Child Dev
ISSN: 0009-3920
eISSN: 1467-8624
Publisher: Oxford University Press (OUP); United States
Grant note: P30 DA027827 / NIDA NIH HHS\r\n5R01HD030588-16A1 / NICHD NIH HHS\r\nR01 HD030588 / NICHD NIH HHS\r\n1P30DA027827 / NIDA NIH HHS
Language: English
Date published: 01/2016
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984070004802771

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