Parent's age and the risk of oral clefts

Camilla BILLE; Axel SKYTTHE; Werner VACH; Lisbeth B KNUDSEN; Anne-Marie Nybo ANDERSEN; Jeffrey C MURRAY; Kaare CHRISTENSEN

doi:10.1097/01.ede.0000158745.84019.c2

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Parent's age and the risk of oral clefts

Journal article

Peer reviewed

Parent's age and the risk of oral clefts

Camilla BILLE, Axel SKYTTHE, Werner VACH, Lisbeth B KNUDSEN, Anne-Marie Nybo ANDERSEN, Jeffrey C MURRAY and Kaare CHRISTENSEN

Epidemiology (Cambridge, Mass.), Vol.16(3), pp.311-316

2005

DOI: 10.1097/01.ede.0000158745.84019.c2

PMCID: PMC2839123

PMID: 15824545

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Abstract

Background: Some malformations are clearly associated with older maternal age, but the effect of older age of the father is less certain. The aim of this study is to determine the degree to which maternal age and paternal age independently influence the risk of having a child with oral clefts. Methods: Among the 1,489,014 live births in Denmark during 1973-1996, there were 1920 children with nonsyndromic cleft lip with or without cleft palate and 956 children with nonsyndromic cleft palate. We used logistic regression to assess the impact of parental age on the occurrence of cleft lip with or without cleft palate and cleft palate. Interaction between mother's and father's age was included in the analysis. Results: Separate analyses of mother's and father's age showed that older age was associated with increased risk of both cleft lip with or without cleft palate and cleft palate only. In a joint analysis, both maternal and paternal ages were associated with the risk of cleft lip with or without cleft palate, but the contribution of each was dependent on the age of the other parent. In the analysis of cleft palate only, the effect of maternal age disappeared, leaving only paternal age as a risk factor. Conclusion: Both high maternal age and high paternal age were associated with cleft lip with or without cleft palate. Higher paternal age but not maternal age increased the risk of cleft palate only.

Public health. Hygiene-occupational medicine

Public health. Hygiene

Miscellaneous

Otorhinolaryngology. Stomatology

Non tumoral diseases

Biological and medical sciences

Medical sciences

Facial bones, jaws, teeth, parodontium: diseases, semeiology

Details

Title: Subtitle: Parent's age and the risk of oral clefts
Creators: Camilla BILLE - Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Axel SKYTTHE - Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Werner VACH - Department of Statistics, University of Southern Denmark, Odense, Denmark
Lisbeth B KNUDSEN - Department of Social Studies and Organization, Aalborg University, Aalborg, Denmark
Anne-Marie Nybo ANDERSEN - Department of Social Medicine, University of Copenhagen, Copenhagen, Denmark
Jeffrey C MURRAY - Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Kaare CHRISTENSEN - Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Resource Type: Journal article
Publication Details: Epidemiology (Cambridge, Mass.), Vol.16(3), pp.311-316
DOI: 10.1097/01.ede.0000158745.84019.c2
PMID: 15824545
PMCID: PMC2839123
NLM abbreviation: Epidemiology
ISSN: 1044-3983
eISSN: 1531-5487
Publisher: Lippincott Williams & Wilkins; Philadelphia, PA
Language: English
Date published: 2005
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
Record Identifier: 9984025698202771

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