Journal article
Parkinson’s Disease Dementia and Dementia with Lewy Bodies Have Similar Neuropsychological Profiles
Frontiers in neurology, Vol.9, pp.123-123
03/12/2018
DOI: 10.3389/fneur.2018.00123
PMCID: PMC5857567
PMID: 29593630
Abstract
Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are common causes of dementia worldwide. Although considered separate entities based on the relative temporal onset of motor symptoms vs. diagnosis of dementia, it is unknown if these diseases truly have distinct cognitive profiles. We hypothesized that patients divided into PDD and DLB categories strictly by temporal criteria would have different neuropsychological profiles. We investigated this question
via
neuropsychological testing of PDD and DLB patients at the University of Iowa. We performed retrospective chart analysis and review of neuropsychological testing of clinically diagnosed patients with PDD or DLB, who had presented to University of Iowa’s dementia and movement disorder clinics. Forty-seven patients diagnosed by the treating neurologist as PDD or DLB were included. Neuropsychological performance was compared between groups, and as a function of the relative timing of the motor diagnosis vs. diagnosis of dementia. We found that both PDD and DLB patients showed severe deficits in executive function, visual–spatial processing, and verbal learning. However, we found no significant differences in neuropsychological performance between groups, and neuropsychological performance could not reliably account for the relative timing of motor diagnosis vs. diagnosis of dementia. Our data support the idea that DLB and PDD are on a neuropsychological spectrum.
Details
- Title: Subtitle
- Parkinson’s Disease Dementia and Dementia with Lewy Bodies Have Similar Neuropsychological Profiles
- Creators
- Georgina M Aldridge - Department of Neurology, University of IowaAllison Birnschein - Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children’s Hospital Medical CenterNatalie L Denburg - Department of Neurology, University of IowaNandakumar S Narayanan - Department of Neurology, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Frontiers in neurology, Vol.9, pp.123-123
- DOI
- 10.3389/fneur.2018.00123
- PMID
- 29593630
- PMCID
- PMC5857567
- NLM abbreviation
- Front Neurol
- ISSN
- 1664-2295
- eISSN
- 1664-2295
- Publisher
- Frontiers Media S.A
- Grant note
- R25 NS079173 / National Institutes of Health 1R01NS100849-01A1 / National Institute of Neurological Disorders and Stroke
- Language
- English
- Date published
- 03/12/2018
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984020723902771
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