Journal article
Partial Replacement with Menhaden Oil Improves Peripheral Neuropathy in High-Fat-Fed Low-Dose Streptozotocin Type 2 Diabetic Rat
Journal of nutrition and metabolism, Vol.2012, pp.950517-8
2012
DOI: 10.1155/2012/950517
PMCID: PMC3439986
PMID: 22988492
Abstract
Aims
. To determine the effect of partial replacement of a high-fat diet with menhaden oil on diabetic neuropathy in an animal model of type 2 diabetes.
Materials and Methods
. High-fat/low-dose streptozotocin diabetic rats were used to examine the influence of replacing 50% of the source of the high-fat diet (lard) with menhaden oil, a natural source of n-3 fatty acids, on diabetic neuropathy. Endpoints included analyses of glucose tolerance, fatty liver disease, serum and liver fatty acid composition, serum lipid and adiponectin levels, motor and sensory nerve conduction velocity, thermal sensitivity and innervation of the hindpaw.
Results
. Diabetic rats were insulin resistant and menhaden oil did not improve whole animal glucose utilization. Menhaden oil did not improve elevated HbA
1
C levels or serum lipid levels but serum levels of adiponectin were significantly increased and hepatic steatosis was significantly improved. Diabetic rats were thermal hypoalgesic, had reduced motor and sensory nerve conduction velocities and intraepidermal nerve fiber profiles were decreased in the hindpaw and these endpoints were significantly improved with menhaden oil.
Conclusions
. We found that enrichment of a high-fat diet with menhaden oil improved a number of endpoints associated with diabetic neuropathy.
Details
- Title: Subtitle
- Partial Replacement with Menhaden Oil Improves Peripheral Neuropathy in High-Fat-Fed Low-Dose Streptozotocin Type 2 Diabetic Rat
- Creators
- Lawrence J Coppey - Department of Internal Medicine, University of Iowa, Iowa City, IA 52246, USAAmey Holmes - Iowa City VA Health Care System, U.S. Department of Veterans Affairs, Iowa City, IA 52246, USAEric P Davidson - Department of Internal Medicine, University of Iowa, Iowa City, IA 52246, USAMark A Yorek - Department of Internal Medicine, University of Iowa, Iowa City, IA 52246, USA
- Resource Type
- Journal article
- Publication Details
- Journal of nutrition and metabolism, Vol.2012, pp.950517-8
- DOI
- 10.1155/2012/950517
- PMID
- 22988492
- PMCID
- PMC3439986
- NLM abbreviation
- J Nutr Metab
- ISSN
- 2090-0724
- eISSN
- 2090-0732
- Publisher
- Hindawi Publishing Corporation
- Grant note
- DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases, award: DK073990, BX001680
- Language
- English
- Date published
- 2012
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984094604002771
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