Journal article
Partial versus radical nephrectomy in clinical T2 renal masses
International journal of urology, Vol.28(11), pp.1149-1154
11/2021
DOI: 10.1111/iju.14664
PMID: 34382267
Abstract
To report perioperative, renal functional and oncologic outcomes for patients undergoing partial or radical nephrectomy for cT2 renal masses.
Retrospective review of patients who underwent partial (n = 72) or radical nephrectomy (n = 379) for cT2 renal masses from 2000 to 2016. After propensity adjustment using inverse probability weighting, the following were compared by surgery (partial or radical nephrectomy): complications, renal function measured by estimated glomerular filtration rate as continuous and as <60 mL/min/1.73 m
at 1 and 3 years postoperatively and overall, metastases-free survival and cancer-specific survival in patients with renal cell carcinoma.
After propensity adjustment, clinical and radiographic features were well-balanced between groups. Overall and severe complications were more common for partial compared with radical nephrectomy, although not statistically significant (19 vs 13%, P = 0.14 and 4 vs 2%, P = 0.3, respectively). Estimated glomerular filtration rate change at 1 and 3 years was more pronounced in radical compared with partial nephrectomy (median -16 vs -5 and -14 vs -2, respectively, P < 0.001). A greater proportion of radical nephrectomy patients had an estimated glomerular filtration rate <60 at 1 and 3 years (55 vs 17% and 48 vs 17%, respectively, P < 0.01). In renal cell carcinoma patients, overall, metastases-free and cancer-specific survival were not significantly different between groups (median survivor follow up 7.1 years, interquartile range 3.6-11.4).
Partial nephrectomy appears to be a relatively safe and a potentially effective treatment for cT2 renal masses, conferring better renal functional preservation compared with radical nephrectomy. These data support continued use of partial nephrectomy for renal masses >7 cm in appropriately selected patients.
Details
- Title: Subtitle
- Partial versus radical nephrectomy in clinical T2 renal masses
- Creators
- Dane E Klett - Mayo ClinicMatvey Tsivian - Mayo ClinicVignesh T Packiam - Mayo ClinicChristine M Lohse - Mayo ClinicMohamed E Ahmed - Mayo ClinicTheodora A Potretzke - Mayo ClinicAjay Gopalakrishna - Mayo ClinicStephen A Boorjian - Mayo ClinicR Houston Thompson - Mayo ClinicBradley C Leibovich - Mayo ClinicAaron M Potretzke - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- International journal of urology, Vol.28(11), pp.1149-1154
- DOI
- 10.1111/iju.14664
- PMID
- 34382267
- ISSN
- 0919-8172
- eISSN
- 1442-2042
- Language
- English
- Date published
- 11/2021
- Academic Unit
- Urology
- Record Identifier
- 9984320858002771
Metrics
12 Record Views