Particles and Prejudice: Nanomedicine Approaches to Reducing Health Disparities in Endometrial Cancer

Claire E Rowlands; Abigail M Folberg; Zachary K Beickman; Eric J Devor; Kimberly K Leslie; Brittany E Givens

doi:10.1002/smll.202300096

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Particles and Prejudice: Nanomedicine Approaches to Reducing Health Disparities in Endometrial Cancer

Journal article

Peer reviewed

Particles and Prejudice: Nanomedicine Approaches to Reducing Health Disparities in Endometrial Cancer

Claire E Rowlands, Abigail M Folberg, Zachary K Beickman, Eric J Devor, Kimberly K Leslie and Brittany E Givens

Small (Weinheim an der Bergstrasse, Germany), Vol.20(41), e2300096

10/10/2024

DOI: 10.1002/smll.202300096

PMCID: PMC10716380

PMID: 37312613

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10716380/pdf/nihms-1913786.pdfView

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Abstract

Endometrial cancer is the most common gynecological malignancy worldwide and unfortunately has a much higher mortality rate in Black women compared with White women. Many potential factors contribute to these mortality rates, including the underlying effects of systemic and interpersonal racism. Furthermore, other trends in medicine have potential links to these rates including participation in clinical trials, hormone therapy, and pre-existing health conditions. Addressing the high incidence and disparate mortality rates in endometrial cancer requires novel methods, such as nanoparticle-based therapeutics. These therapeutics have been growing in increasing prevalence in pre-clinical development and have far-reaching implications in cancer therapy. The rigor of pre-clinical studies is enhanced by the likeness of the model to the human body. In systems for 3D cell culture, for example, the extracellular matrix mimics the tumor more closely. The increasing emphasis on precision medicine can be applied to cancer using nanoparticle-based methods and applied to pre-clinical models by using patient-derived model data. This review highlights the intersections of nanomedicine, precision medicine, and racial disparities within endometrial cancer and provides insights into reducing health disparities using recent scientific advances on the nanoscale.

Details

Title: Subtitle: Particles and Prejudice: Nanomedicine Approaches to Reducing Health Disparities in Endometrial Cancer
Creators: Claire E Rowlands - University of Kentucky
Abigail M Folberg - University of Nebraska at Omaha
Zachary K Beickman - Purdue University West Lafayette
Eric J Devor - University of Iowa
Kimberly K Leslie - University of New Mexico
Brittany E Givens - University of Kentucky
Resource Type: Journal article
Publication Details: Small (Weinheim an der Bergstrasse, Germany), Vol.20(41), e2300096
DOI: 10.1002/smll.202300096
PMID: 37312613
PMCID: PMC10716380
NLM abbreviation: Small
ISSN: 1613-6810
eISSN: 1613-6829
Publisher: Wiley
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: 2R01CA 99908‐16A1; DOI: 10.13039/100006108, name: National Center for Advancing Translational Sciences, award: UL1TR001998; DOI: 10.13039/100000005, name: U.S. Department of Defense, award: OC190352, CA210610
Language: English
Electronic publication date: 06/13/2023
Date published: 10/10/2024
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9984436455202771

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