Journal article
Passage to India: The search for genes causing autosomal recessive nonsyndromic hearing loss
Otolaryngology--head and neck surgery, Vol.118(3), pp.333-337
1998
DOI: 10.1016/S0194-5998(98)70311-0
PMID: 9527113
Abstract
Hereditary hearing impairment affects approximately 0.05% of all children born in the United States. It is most commonly autosomal recessive, nonsyndromic, and monogenic (autosomal recessive nonsyndromic hearing loss [ARNSHL]). Although the number of disease loci is not known, some estimates exceed 100. Using a strategy of homozygosity mapping to localize ARNSHL genes by screening consanguineous families for chromosomal regions that are homozygous by descent, we have mapped several genes in multiplex, nuclear, consanguineous families in Tamil Nadu, India. From the mean frequency of the ARNSHL genes in this population, the total number of disease genes is estimated to be 57. (Otolaryngol Head Neck Surg 1998;118:333-7.)
Details
- Title: Subtitle
- Passage to India: The search for genes causing autosomal recessive nonsyndromic hearing loss
- Creators
- Ross I.S ZbarArabandi RameshC.R.Srikumari SrisailapathyKunihiro FukushimaSigrid WayneRichard J.H Smith
- Resource Type
- Journal article
- Publication Details
- Otolaryngology--head and neck surgery, Vol.118(3), pp.333-337
- DOI
- 10.1016/S0194-5998(98)70311-0
- PMID
- 9527113
- NLM abbreviation
- Otolaryngol Head Neck Surg
- ISSN
- 0194-5998
- eISSN
- 1097-6817
- Publisher
- Mosby, Inc
- Language
- English
- Date published
- 1998
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984006428602771
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