Journal article
Past, present, and future of hormonal therapy in recurrent endometrial cancer
International journal of women's health, Vol.6(1), pp.429-435
01/01/2014
DOI: 10.2147/IJWH.S40942
PMCID: PMC4014387
PMID: 24833920
Abstract
Endometrial cancer is a heterogeneous disease. Type I cancers are hormonally driven, typically present with a low grade at an early stage, and are of endometrioid histology. These cancers are often cured by surgery, and the rate of recurrence is low. Type II cancers are less differentiated, often appear at a later stage, and are of serous, clear cell, or high grade endometrioid histology. The risk of recurrence in these cancers is much higher than with type I tumors. Isolated pelvic recurrences can be treated with radiation or exenteration, but systemic disease is fatal. It is in these recurrent patients, where prolongation of progression-free survival is the goal, that hormonal therapy can have the greatest benefit. In selected patients, hormonal therapy can be as effective as cytotoxic chemotherapy, without the toxicity and at a much lower cost. Here we review the evidence for treatment of patients suffering from recurrent endometrial cancer with hormonal therapy and explore avenues for the future of hormonal treatment of endometrial cancer. Currently, progesterone is the hormonal treatment of choice in these patients. Other drugs are also used, including selective estrogen receptor modulators, aromatase inhibitors, and gonadotropin-releasing hormone antagonists. Hormonal treatment of recurrent endometrial cancer relies on expression of the hormone receptors, which act as nuclear transcription factors. Tumors that express these receptors are the most sensitive to therapy; it is for this reason that patient selection is vitally important to the successful treatment of recurrent endometrial cancer with hormonal therapy.
Details
- Title: Subtitle
- Past, present, and future of hormonal therapy in recurrent endometrial cancer
- Creators
- Matthew J. Carlson - Univ Iowa, Dept Obstet & Gynecol, 200 Hawkins Dr, Iowa City, IA 52242 USAKristina W. Thiel - University of IowaKimberly K. Leslie - University of Iowa
- Resource Type
- Journal article
- Publication Details
- International journal of women's health, Vol.6(1), pp.429-435
- DOI
- 10.2147/IJWH.S40942
- PMID
- 24833920
- PMCID
- PMC4014387
- NLM abbreviation
- Int J Womens Health
- ISSN
- 1179-1411
- eISSN
- 1179-1411
- Publisher
- Dove Medical Press Ltd
- Number of pages
- 7
- Grant note
- R01CA099908 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01 CA099908 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 01/01/2014
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984383914202771
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