Patent Ductus Arteriosus: A Contemporary Perspective for the Pediatric and Adult Cardiac Care Provider

Carl H. Backes; Kevin D. Hill; Elaine L. Shelton; Jonathan L. Slaughter; Tamorah R. Lewis; Dany E. Weisz; May Ling Mah; Shazia Bhombal; Charles V. Smith; Patrick J. McNamara; William E. Benitz; Vidu Garg

doi:10.1161/JAHA.122.025784

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Patent Ductus Arteriosus: A Contemporary Perspective for the Pediatric and Adult Cardiac Care Provider

Journal article

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Patent Ductus Arteriosus: A Contemporary Perspective for the Pediatric and Adult Cardiac Care Provider

Carl H. Backes, Kevin D. Hill, Elaine L. Shelton, Jonathan L. Slaughter, Tamorah R. Lewis, Dany E. Weisz, May Ling Mah, Shazia Bhombal, Charles V. Smith, Patrick J. McNamara, …

Journal of the American Heart Association, Vol.11(17), pp.e025784-e025784

09/06/2022

DOI: 10.1161/JAHA.122.025784

PMCID: PMC9496432

PMID: 36056734

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Abstract

The burden of patent ductus arteriosus (PDA) continues to be significant. In view of marked differences in preterm infants versus more mature, term counterparts (viewed on a continuum with adolescent and adult patients), mechanisms regulating ductal patency, genetic contributions, clinical consequences, and diagnostic and treatment thresholds are discussed separately, when appropriate. Among both preterm infants and older children and adults, a range of hemodynamic profiles highlighting the markedly variable consequences of the PDA are provided. In most contemporary settings, transcatheter closure is preferable over surgical ligation, but data on longer‐term outcomes, particularly among preterm infants, are lacking. The present review provides recommendations to identify gaps in PDA diagnosis, management, and treatment on which subsequent research can be developed. Ultimately, the combination of refined diagnostic thresholds and expanded treatment options provides the best opportunities to address the burden of PDA. Although fundamental gaps remain unanswered, the present review provides pediatric and adult cardiac care providers with a contemporary framework in PDA care to support the practice of evidence‐based medicine.

Details

Title: Subtitle: Patent Ductus Arteriosus: A Contemporary Perspective for the Pediatric and Adult Cardiac Care Provider
Creators: Carl H. Backes - Nationwide Children's Hospital
Kevin D. Hill - Duke University
Elaine L. Shelton - Vanderbilt University Medical Center
Jonathan L. Slaughter - Nationwide Children's Hospital
Tamorah R. Lewis - University of Missouri–Kansas City
Dany E. Weisz - University of Toronto
May Ling Mah - The Ohio State University
Shazia Bhombal - Lucile Packard Children's Hospital
Charles V. Smith - University of Washington
Patrick J. McNamara - University of Iowa
William E. Benitz - Lucile Packard Children's Hospital
Vidu Garg - The Ohio State University
Resource Type: Journal article
Publication Details: Journal of the American Heart Association, Vol.11(17), pp.e025784-e025784
DOI: 10.1161/JAHA.122.025784
PMID: 36056734
PMCID: PMC9496432
NLM abbreviation: J Am Heart Assoc
ISSN: 2047-9980
eISSN: 2047-9980
Language: English
Date published: 09/06/2022
Academic Unit: Stead Family Department of Pediatrics; Neonatology; Internal Medicine
Record Identifier: 9984354146202771

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