Journal article
Patent Ductus Arteriosus-Time for a Definitive Trial
Clinics in perinatology, Vol.47(3), pp.617-639
09/2020
DOI: 10.1016/j.clp.2020.05.007
PMID: 32713454
Abstract
More than 70 randomized controlled trials have been conducted on the management of patent ductus arteriosus (PDA) in preterm infants. Yet, clinicians are unsure if treating a PDA improves clinically important outcomes. Earlier clinical trials have primarily explored which pharmacotherapeutic agent effectively closes the PDA. Because many of these trials included older infants, had widely varying PDA definitions, and provided open-label treatment, it is difficult to draw inferences on clinical outcomes based on the results of these trials. These flaws in trial design might have contributed to the growing notion that "no treatment" is a feasible option irrespective of the clinical characteristics of the infant and the PDA shunt volume.
Details
- Title: Subtitle
- Patent Ductus Arteriosus-Time for a Definitive Trial
- Creators
- Souvik Mitra - Department of Pediatrics, Dalhousie University, G-2214, 5850/5980 University Avenue, Halifax, Nova Scotia B3K 6R8, Canada; Department of Community Health & Epidemiology, Dalhousie University, G-2214, 5850/5980 University Avenue, Halifax, Nova Scotia B3K 6R8, Canada. Electronic address: https://twitter.com/souvik_neoPatrick J McNamara - Department of Pediatrics, University of Iowa, 200 Hawkins Drive, 8803 JPP, Iowa City, IA 52242, USA; Department of Internal Medicine, University of Iowa, 200 Hawkins Drive, 8803 JPP, Iowa City, IA 52242, USA. Electronic address: patrick-mcnamara@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Clinics in perinatology, Vol.47(3), pp.617-639
- Publisher
- United States
- DOI
- 10.1016/j.clp.2020.05.007
- PMID
- 32713454
- ISSN
- 0095-5108
- eISSN
- 1557-9840
- Language
- English
- Date published
- 09/2020
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology; Internal Medicine
- Record Identifier
- 9984066112702771
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