Patent ductus arteriosus (PDA) and response to late surfactant treatment in premature infants

Madeline S Beauchene; Alison M Cunningham; Amy H Stanford; Adrianne R Bischoff; John M Dagle; Danielle R Rios; Jonathan M Klein; Regan E Giesinger; Patrick J McNamara

doi:10.1038/s41372-023-01689-2

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Patent ductus arteriosus (PDA) and response to late surfactant treatment in premature infants

Journal article

Peer reviewed

Patent ductus arteriosus (PDA) and response to late surfactant treatment in premature infants

Madeline S Beauchene, Alison M Cunningham, Amy H Stanford, Adrianne R Bischoff, John M Dagle, Danielle R Rios, Jonathan M Klein, Regan E Giesinger and Patrick J McNamara

Journal of perinatology, Vol.43(10), pp.1245-1251

10/2023

DOI: 10.1038/s41372-023-01689-2

PMID: 37160976

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Abstract

To determine the clinical/echocardiography (ECHO) phenotype of patients with hypoxic respiratory failure (HRF) and response to late surfactant, according to patent ductus arteriosus (PDA) status. This retrospective study included infants ≤26 weeks gestation who received ≥1 surfactant dose after 6 postnatal days and where PDA status was available by ECHO. Response to surfactant was appraised based on change in respiratory severity score over 48 h. The relationship between PDA status and response to surfactant was evaluated via univariate analysis. We studied late surfactant (n = 71 doses) administration in 35 preterm infants born at a mean weight and GA at birth were 595 g (508, 696) and 23.3 (22.7, 25) weeks, respectively of whom 16 (46%) had a diagnosis of PDA. Positive response to late surfactant treatment was independently associated with absence of PDA [OR 26 (2, 334), p = 0.01] whereas presence of PDA was independently associated with negative response [OR 12 (1.1, 126), p = 0.04]. In neonates ≤26 weeks gestation, with HRF, response to surfactant after postnatal day 6 is influenced by PDA status. Future trials should consider PDA status which may enhance diagnostic precision and refine patient selection for late surfactant treatment.

Details

Title: Subtitle: Patent ductus arteriosus (PDA) and response to late surfactant treatment in premature infants
Creators: Madeline S Beauchene - Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, USA
Alison M Cunningham - Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, USA
Amy H Stanford - Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, USA
Adrianne R Bischoff - Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, USA
John M Dagle - University of Iowa
Danielle R Rios - Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, USA
Jonathan M Klein - Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, USA
Regan E Giesinger - Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, USA
Patrick J McNamara - Department of Internal Medicine, The University of Iowa, Iowa City, IA, USA. patrick-mcnamara@uiowa.edu
Resource Type: Journal article
Publication Details: Journal of perinatology, Vol.43(10), pp.1245-1251
DOI: 10.1038/s41372-023-01689-2
PMID: 37160976
ISSN: 0743-8346
eISSN: 1476-5543
Language: English
Electronic publication date: 05/09/2023
Date published: 10/2023
Academic Unit: Stead Family Department of Pediatrics; Epidemiology; Biochemistry and Molecular Biology; Neonatology; Internal Medicine
Record Identifier: 9984406605202771

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