Journal article
Patent ductus arteriosus: The physiology of transition
Seminars in fetal & neonatal medicine, Vol.23(4), pp.225-231
08/2018
DOI: 10.1016/j.siny.2018.05.001
PMID: 29779927
Abstract
The transition from intrauterine to extrauterine life represents a critical phase of physiological adaptation which impacts many organ systems, most notably the heart and the lungs. The majority of term neonates complete this transition without complications; however, dysregulation of normal postnatal adaptation may lead to acute cardiopulmonary instability, necessitating advanced intensive care support. Although not as well appreciated as changes in vascular resistances, the shunt across the DA plays a crucial physiologic role in the adaptive processes related to normal transitional circulation. Further, we describe key differences in the behavior of the ductal shunt during transition in preterm neonates and we postulate mechanisms through which the DA may modulate major hemodynamic complications during this vulnerable period. Finally, we describe the conditions in which preservation of ductal patency is a desired clinical goal and we discuss clinical factors that may determine adequate balance between pulmonary and systemic circulation.
Details
- Title: Subtitle
- Patent ductus arteriosus: The physiology of transition
- Creators
- Poorva Deshpande - Department of Pediatrics, Mount Sinai Hospital, Toronto, Canada; Department of Pediatrics, University of Toronto, Toronto, CanadaMichelle Baczynski - Respiratory Therapy, Mount Sinai Hospital, Toronto, CanadaPatrick J McNamara - Department of Pediatrics, University of Toronto, Toronto, Canada; Division of Neonatology, Hospital for Sick Children, Toronto, CanadaAmish Jain - Department of Pediatrics, Mount Sinai Hospital, Toronto, Canada; Department of Pediatrics, University of Toronto, Toronto, Canada. Electronic address: amish.jain@sinaihealthsystem.ca
- Resource Type
- Journal article
- Publication Details
- Seminars in fetal & neonatal medicine, Vol.23(4), pp.225-231
- DOI
- 10.1016/j.siny.2018.05.001
- PMID
- 29779927
- ISSN
- 1744-165X
- eISSN
- 1878-0946
- Language
- English
- Date published
- 08/2018
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology; Internal Medicine
- Record Identifier
- 9984093483902771
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