Paternal and joint parental occupational pesticide exposure and spina bifida in the National Birth Defects Prevention Study, 1997 to 2002

Stacy M Pettigrew; Erin M Bell; Alissa R Van Zutphen; Carissa M Rocheleau; Gary M Shaw; Paul A Romitti; Andrew Olshan; Philip J Lupo; Aida Soim; Jennifer A Makelarski; Adrian M Michalski; Wayne Sanderson; and the National Birth Defects Prevention Study

doi:10.1002/bdra.23551

Back

Paternal and joint parental occupational pesticide exposure and spina bifida in the National Birth Defects Prevention Study, 1997 to 2002

Journal article

Open access

Peer reviewed

Paternal and joint parental occupational pesticide exposure and spina bifida in the National Birth Defects Prevention Study, 1997 to 2002

Stacy M Pettigrew, Erin M Bell, Alissa R Van Zutphen, Carissa M Rocheleau, Gary M Shaw, Paul A Romitti, Andrew Olshan, Philip J Lupo, Aida Soim, Jennifer A Makelarski, …

Birth defects research. A Clinical and molecular teratology, Vol.106(11), pp.963-971

11/2016

DOI: 10.1002/bdra.23551

PMCID: PMC6613649

PMID: 27891778

View Online

Abstract

Because of persistent concerns over the association between pesticides and spina bifida, we examined the role of paternal and combined parental occupational pesticide exposures in spina bifida in offspring using data from a large population-based study of birth defects. Occupational information from fathers of 291 spina bifida cases and 2745 unaffected live born control infants with estimated dates of delivery from 1997 to 2002 were collected by means of maternal report. Two expert industrial hygienists estimated exposure intensity and frequency to insecticides, herbicides, and fungicides. Multivariable logistic regression models were used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI) for exposure to any pesticide and to any class of pesticide (yes/no; and by median), and exposure to combinations of pesticides (yes/no) and risk of spina bifida. Adjusted odds ratios were also estimated by parent exposed to pesticides (neither, mother only, father only, both parents). Joint parental occupational pesticide exposure was positively associated with spina bifida (aOR, 1.5; 95% CI, 0.9-2.4) when compared with infants with neither maternal nor paternal exposures; a similar association was not observed when only one parent was exposed. There was a suggested positive association between combined paternal insecticide and fungicide exposures and spina bifida (aOR, 1.5; 95% CI, 0.8-2.8), however, nearly all other aORs were close to unity. Overall, there was little evidence paternal occupational pesticide exposure was associated with spina bifida. However, the small numbers make it difficult to precisely evaluate the role of pesticide classes, individually and in combination. Birth Defects Research (Part A) 106:963-971, 2016. © 2016 Wiley Periodicals, Inc.

Paternal Exposure - adverse effects

Spinal Dysraphism - epidemiology

Occupational Exposure - adverse effects

Pesticides - toxicity

Humans

Maternal Exposure - adverse effects

Female

Male

Retrospective Studies

Spinal Dysraphism - chemically induced

Details

Title: Subtitle: Paternal and joint parental occupational pesticide exposure and spina bifida in the National Birth Defects Prevention Study, 1997 to 2002
Creators: Stacy M Pettigrew - Department of Environmental Health Sciences, The University at Albany, State University of New York, Rensselaer, New York
Erin M Bell - Department of Environmental Health Sciences, The University at Albany, State University of New York, Rensselaer, New York
Alissa R Van Zutphen - Bureau of Environmental and Occupational Epidemiology, New York State Department of Health, Albany, New York
Carissa M Rocheleau - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio
Gary M Shaw - Department of Pediatrics, Stanford University, Stanford, California
Paul A Romitti - Department of Epidemiology, The University of Iowa, Iowa City, Iowa
Andrew Olshan - Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina
Philip J Lupo - Department of Pediatrics, Baylor College of Medicine, Houston, Texas
Aida Soim - Bureau of Environmental and Occupational Epidemiology, New York State Department of Health, Albany, New York
Jennifer A Makelarski - Department of Obstetrics and Gynecology, The University of Chicago, Chicago, Illinois
Adrian M Michalski - Bureau of Environmental and Occupational Epidemiology, New York State Department of Health, Albany, New York
Wayne Sanderson - Departments of Epidemiology, and Preventative Medicine and Environmental Health, University of Kentucky College of Public Health, Lexington, Kentucky
and the National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: Birth defects research. A Clinical and molecular teratology, Vol.106(11), pp.963-971
DOI: 10.1002/bdra.23551
PMID: 27891778
PMCID: PMC6613649
NLM abbreviation: Birth Defects Res A Clin Mol Teratol
ISSN: 1542-0752
eISSN: 1542-0760
Publisher: Wiley; United States
Grant note: P30 ES005605 / NIEHS NIH HHS P2C HD050924 / NICHD NIH HHS
Language: English
Date published: 11/2016
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983995011402771

Metrics

35 Record Views

5 Times Cited - Web of Science

See more details