Paternal dominance of trans-eQTL influences gene expression patterns in maize hybrids

Ruth A Swanson-Wagner; Rhonda DeCook; Yi Jia; Tim Bancroft; Tieming Ji; Xuefeng Zhao; Dan Nettleton; Patrick S Schnable

doi:10.1126/science.1178294

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Paternal dominance of trans-eQTL influences gene expression patterns in maize hybrids

Journal article

Peer reviewed

Paternal dominance of trans-eQTL influences gene expression patterns in maize hybrids

Ruth A Swanson-Wagner, Rhonda DeCook, Yi Jia, Tim Bancroft, Tieming Ji, Xuefeng Zhao, Dan Nettleton and Patrick S Schnable

Science (American Association for the Advancement of Science), Vol.326(5956), pp.1118-1120

11/20/2009

DOI: 10.1126/science.1178294

PMID: 19965432

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Abstract

Heterosis refers to the superior performance of hybrid progeny relative to their inbred parents, but the mechanisms responsible are unknown. Hybrids between the maize inbred lines B73 and Mo17 exhibit heterosis regardless of cross direction. These reciprocal hybrids differ from each other phenotypically, and 30 to 50% of their genes are differentially expressed. We identified approximately 4000 expression quantitative trait loci (eQTL) that allowed us to identify markers linked to variation in expression. We found that over three-quarters of these eQTL act in trans (78%) and that 86% of these differentially regulate transcript accumulation in a manner consistent with gene expression in the hybrid being regulated exclusively by the paternally transmitted allele. This result suggests that widespread imprinting contributes to the regulation of gene expression in maize hybrids.

Phenotype

Genomic Imprinting

Zea mays - genetics

Oligonucleotide Array Sequence Analysis

Genes, Plant

Chromosome Mapping

Gene Expression Profiling

Genome, Plant

Hybrid Vigor

Hybridization, Genetic

Gene Expression Regulation, Plant

Inbreeding

Zea mays - physiology

Quantitative Trait Loci

Crosses, Genetic

Details

Title: Subtitle: Paternal dominance of trans-eQTL influences gene expression patterns in maize hybrids
Creators: Ruth A Swanson-Wagner - Iowa State University, Ames, IA 50011, USA
Rhonda DeCook
Yi Jia
Tim Bancroft
Tieming Ji
Xuefeng Zhao
Dan Nettleton
Patrick S Schnable
Resource Type: Journal article
Publication Details: Science (American Association for the Advancement of Science), Vol.326(5956), pp.1118-1120
DOI: 10.1126/science.1178294
PMID: 19965432
NLM abbreviation: Science
ISSN: 1095-9203
eISSN: 1095-9203
Publisher: United States
Language: English
Date published: 11/20/2009
Academic Unit: Statistics and Actuarial Science
Record Identifier: 9983986000202771

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