Journal article
Paternal occupation and birth defects: findings from the National Birth Defects Prevention Study
Occupational and environmental medicine (London, England), Vol.69(8), pp.534-542
08/2012
DOI: 10.1136/oemed-2011-100372
PMCID: PMC3744212
PMID: 22782864
Abstract
ObjectivesSeveral epidemiological studies have suggested that certain paternal occupations may be associated with an increased prevalence of birth defects in offspring. Using data from the National Birth Defects Prevention Study, the authors investigated the association between paternal occupation and birth defects in a case–control study of cases comprising over 60 different types of birth defects (n=9998) and non-malformed controls (n=4066) with dates of delivery between 1997 and 2004.MethodsUsing paternal occupational histories reported by mothers via telephone interview, jobs were systematically classified into 63 groups based on shared exposure profiles within occupation and industry. Data were analysed using Bayesian logistic regression with a hierarchical prior for dependent shrinkage to stabilise estimation with sparse data.ResultsSeveral occupations were associated with an increased prevalence of various birth defect categories, including mathematical, physical and computer scientists; artists; photographers and photo processors; food service workers; landscapers and groundskeepers; hairdressers and cosmetologists; office and administrative support workers; sawmill workers; petroleum and gas workers; chemical workers; printers; material moving equipment operators; and motor vehicle operators.ConclusionsFindings from this study might be used to identify specific occupations worthy of further investigation and to generate hypotheses about chemical or physical exposures common to such occupations.
Details
- Title: Subtitle
- Paternal occupation and birth defects: findings from the National Birth Defects Prevention Study
- Creators
- Tania A Desrosiers - Birth Defects Monitoring Program, State Center for Health Statistics, North Carolina Division of Public Health, Raleigh, North Carolina, USAAmy H Herring - Carolina Population Center, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USAStuart K Shapira - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USAMariëtte Hooiveld - Netherlands Institute for Health Services Research, Utrecht, The NetherlandsTom J Luben - National Center for Environmental Assessment, US Environmental Protection Agency, Research Triangle Park, North Carolina, USAMichele L Herdt-Losavio - Center for Environmental Health, New York State Department of Health, Troy, New York, USAShao Lin - Center for Environmental Health, New York State Department of Health, Troy, New York, USAAndrew F Olshan - Carolina Population Center, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USANational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- Occupational and environmental medicine (London, England), Vol.69(8), pp.534-542
- DOI
- 10.1136/oemed-2011-100372
- PMID
- 22782864
- PMCID
- PMC3744212
- NLM abbreviation
- Occup Environ Med
- ISSN
- 1351-0711
- eISSN
- 1470-7926
- Language
- English
- Date published
- 08/2012
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214810402771
Metrics
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