Journal article
Pathogenesis of cupping of the optic disc
British journal of ophthalmology, Vol.58(10), pp.863-876
02/01/1976
DOI: 10.1136/bjo.58.10.863
PMCID: PMC1215042
PMID: 4375487
Abstract
Recent information derived from (a) clinical and experimental studies on anterior ischaemic optic neuropathy (AION), (b) the pattern of the arterial supply to the anterior part of the optic nerve (ON), and (c) fluorescein fundus angiographic studies related to glaucoma has suggested further progress in the elucidation of the pathogenesis of optic disc cupping (ODC) and cavernous degeneration. Most probably a combination of three factors may be responsible for ODC: (1) Destruction of the neural tissue in the prelaminar region; (2) Backward bowing of the lamina cribrosa which is due to retrolaminar fibrosis and absence of the normal support of the lamina cribrosa posteriorly because of the disappearance of retrolaminar neural tissue; (3) Weakness of the lamina cribrosa. ODC, cavernous degeneration and visual field defects in AION, glaucoma, and low tension glaucoma are considered to be ischaemic and vasogenic in origin, and to be due to interference with the posterior ciliary artery (PCA) supply to the anterior part of the ON either through the rise in intraocular pressure (in glaucoma) or through the fall in perfusion pressure in the PCAs (acute in AION, and chronic in low tension glaucoma).
Details
- Title: Subtitle
- Pathogenesis of cupping of the optic disc
- Creators
- Sohan S Hayreh
- Resource Type
- Journal article
- Publication Details
- British journal of ophthalmology, Vol.58(10), pp.863-876
- DOI
- 10.1136/bjo.58.10.863
- PMID
- 4375487
- PMCID
- PMC1215042
- ISSN
- 0007-1161
- eISSN
- 1468-2079
- Language
- English
- Date published
- 02/01/1976
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984182753902771
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