Journal article
Pathologic Considerations in Gastroenteropancreatic Neuroendocrine Tumors
Surgical oncology clinics of North America, Vol.29(2), pp.185-208
04/2020
DOI: 10.1016/j.soc.2019.11.003
PMCID: PMC7212902
PMID: 32151355
Abstract
This review serves as a primer on contemporary neuroendocrine neoplasm classification, with an emphasis on gastroenteropancreatic well-differentiated neuroendocrine tumors. Topics discussed include general features of neuroendocrine neoplasms, general neuroendocrine marker immunohistochemistry, the distinction of well-differentiated neuroendocrine tumor from pheochromocytoma/paraganglioma and other diagnostic mimics and poorly differentiated neuroendocrine carcinoma from diagnostic mimics, the concepts of differentiation and grade and the application of Ki-67 immunohistochemistry to determine the latter, the various WHO classifications of neuroendocrine neoplasms including the 2019 WHO classification of gastroenteropancreatic tumors, organ-specific considerations for gastroenteropancreatic well-differentiated neuroendocrine tumors, immunohistochemistry to determine site of origin in metastatic well-differentiated neuroendocrine tumor of occult origin, immunohistochemistry in the distinction of well-differentiated neuroendocrine tumor G3 from large cell neuroendocrine carcinoma, and, finally, required and recommended reporting elements for biopsies and resections of gastroenteropancreatic neuroendocrine epithelial neoplasms.
Details
- Title: Subtitle
- Pathologic Considerations in Gastroenteropancreatic Neuroendocrine Tumors
- Creators
- Andrew M Bellizzi - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Surgical oncology clinics of North America, Vol.29(2), pp.185-208
- DOI
- 10.1016/j.soc.2019.11.003
- PMID
- 32151355
- PMCID
- PMC7212902
- NLM abbreviation
- Surg Oncol Clin N Am
- ISSN
- 1055-3207
- eISSN
- 1558-5042
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 04/2020
- Academic Unit
- Pathology
- Record Identifier
- 9984185275802771
Metrics
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