Journal article
Pathological correlates of frontotemporal lobar degeneration in the elderly
Acta neuropathologica, Vol.121(3), pp.365-371
03/01/2011
DOI: 10.1007/s00401-010-0765-z
PMID: 20978901
Abstract
Frontotemporal lobar degeneration (FTLD) is generally recognised as a disorder with presenile onset (that is before 65 years of age) with only occasional cases presenting later than this. We set out to determine what proportion of cases of FTLD had late onset of disease and whether such cases of FTLD had distinctive clinical and neuropathological features as compared to cases with presenile onset. Within a combined Manchester and Newcastle autopsy series of 117 cases with pathologically confirmed FTLD (109/117 cases also met Lund Manchester clinical criteria for FTLD), we identified 30 cases (onset age range 65-86 years), comprising 25% of all FTLD cases ascertained in these two centres over a 25-year period. Neuropathologically, the 30 elderly cases presented features of several FTLD histological subgroups [FTLD-TDP (types 1, 2 and 3, 19 cases (63%)], FLTD-tau [MAPT, PiD and CBD, 10 cases (33%)] and FTLD-UPS (1 case), similar in range of phenotypes to that seen in the presenile group, though patients with MAPT, but not PGRN, mutation, or FUS pathology, were notably absent or fewer in the elderly group. Hippocampal sclerosis (HS) was present in 13/30 of the elderly FTLD cases (43%) compared with 14/79 (18%) (P = 0.012) in the presenile FTLD patients. Lobar atrophy present in most of the younger patients was prominent in only 25% of the elderly subjects. Prospective and retrospective psychiatric and medical case note analysis showed that the majority of the elderly FTLD patients, like their younger counterparts, had behavioural features consistent with frontotemporal dementia. FTLD is common amongst elderly persons and all or most of the major clinical and histological subtypes present in younger individuals can be seen in the older group.
Details
- Title: Subtitle
- Pathological correlates of frontotemporal lobar degeneration in the elderly
- Creators
- Atik Baborie - Walton CentreTimothy D. Griffiths - North Tyneside General HospitalEvelyn Jaros - Royal Victoria InfirmaryIan G. McKeith - Newcastle Hospitals - Campus for Ageing and VitalityDavid J. Burn - Newcastle Hospitals - Campus for Ageing and VitalityAnna Richardson - University of SalfordRaffaele Ferrari - Texas Tech University Health Sciences CenterJorge Moreno - Texas Tech University Health Sciences CenterParastoo Momeni - Texas Tech University Health Sciences CenterDaniel Duplessis - University of SalfordPiyali Pal - University of SalfordSara Rollinson - University of ManchesterStuart Pickering-Brown - University of ManchesterJennifer C. Thompson - University of ManchesterDavid Neary - University of SalfordJulie S. Snowden - University of ManchesterRobert Perry - Royal Victoria InfirmaryDavid M. A. Mann - University of Manchester
- Resource Type
- Journal article
- Publication Details
- Acta neuropathologica, Vol.121(3), pp.365-371
- Publisher
- Springer Nature
- DOI
- 10.1007/s00401-010-0765-z
- PMID
- 20978901
- ISSN
- 0001-6322
- eISSN
- 1432-0533
- Number of pages
- 7
- Grant note
- UK NIHR Biomedical Research Centre for Ageing; National Institutes of Health Research (NIHR) MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Wellcome Trust Age-related disease award to the Newcastle upon Tyne Hospitals NHS Foundation Trust G0502157; G0400074; G0701441; G0900652 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Alzheimer's Society Alzheimers Research Trust G0400074; G0502157; G0900652; G0701441 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
- Language
- English
- Date published
- 03/01/2011
- Academic Unit
- Psychological and Brain Sciences
- Record Identifier
- 9984627307402771
Metrics
4 Record Views