Journal article
Pathology Characterization and Detection of Human Papillomavirus Type 16 in Rectal Squamous Cell Carcinomas
Clinical gastroenterology and hepatology, Vol.17(10), pp.2129-2131
09/2019
DOI: 10.1016/j.cgh.2018.11.006
PMCID: PMC6520215
PMID: 30448596
Abstract
Rectal squamous cell carcinoma (SCC) is a rare tumor with unresolved etiology. Human immunodeficiency virus–infected individuals and solid organ transplant recipients experience >30-fold and approximately 3-fold elevated rates of rectal SCC, respectively, suggesting immunosuppression plays a role.1 Human immunodeficiency virus–infected homosexual men have >60-fold higher rates of rectal SCC, similar to anal SCC. These patterns, which differ from the more common rectal adenocarcinoma (AdCA), raise the possibility of shared etiology between rectal and anal SCC, with human papillomavirus type 16 (HPV16) being a likely candidate.2
Details
- Title: Subtitle
- Pathology Characterization and Detection of Human Papillomavirus Type 16 in Rectal Squamous Cell Carcinomas
- Creators
- Anna E Coghill - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MarylandAndrew M Bellizzi - Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IowaCharles F Lynch - Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IowaMeredith S Shiels - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MarylandFreda R Selk - Iowa Cancer Registry, University of Iowa, Iowa City, IowaMaura Gillison - M.D. Anderson Cancer Center, Houston, TexasBrenda Y Hernandez - University of Hawaii Cancer Center, Honolulu, HawaiiOwen T.M Chan - University of Hawaii Cancer Center, Honolulu, HawaiiEric A Engels - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
- Resource Type
- Journal article
- Publication Details
- Clinical gastroenterology and hepatology, Vol.17(10), pp.2129-2131
- DOI
- 10.1016/j.cgh.2018.11.006
- PMID
- 30448596
- PMCID
- PMC6520215
- NLM abbreviation
- Clin Gastroenterol Hepatol
- ISSN
- 1542-3565
- eISSN
- 1542-7714
- Publisher
- Elsevier Inc
- Grant note
- Intramural Research Program at the National Cancer Institute
- Language
- English
- Date published
- 09/2019
- Academic Unit
- Epidemiology; Pathology
- Record Identifier
- 9983996062202771
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