Journal article
Pathology Laboratory Policies and Procedures for Releasing Diagnostic Tissue for Cancer Research
Archives of pathology & laboratory medicine (1976), Vol.145(2), pp.222-226
06/04/2020
DOI: 10.5858/arpa.2019-0474-OA
PMID: 32496836
Abstract
Context.— The Surveillance, Epidemiology, and End Results (SEER) cancer registry program is currently evaluating the use of archival, diagnostic, formalin-fixed, paraffin-embedded (FFPE) tissue obtained through SEER cancer registries, functioning as honest brokers for deidentified tissue and associated data. To determine the feasibility of this potential program, laboratory policies for sharing tissue for research needed to be assessed. Objective.— To understand the willingness of pathology laboratories to share archival diagnostic tissue for cancer research and related policies. Design.— Seven SEER registries administered a 27-item questionnaire to pathology laboratories within their respective registry catchment areas. Only laboratories that processed diagnostic FFPE specimens and completed the questionnaire were included in the analysis. Results.— Of the 153 responding laboratories, 127 (83%) responded that they process FFPE specimens. Most (n = 88; 69%) were willing to share tissue specimens for research, which was not associated with the number of blocks processed per year by the laboratories. Most laboratories retained the specimens for at least 10 years. Institutional regulatory policies on sharing deidentified tissue varied considerably, ranging from requiring a full Institutional Review Board review to considering such use exempt from Institutional Review Board review, and 43% (55 of 127) of the laboratories did not know their terms for sharing tissue for research. Conclusions.— This project indicated a general willingness of pathology laboratories to participate in research by sharing FFPE tissue. Given the variability of research policies across laboratories, it is critical for each SEER registry to work with laboratories in their catchment area to understand such policies and state legislation regulating tissue retention and guardianship.
Details
- Title: Subtitle
- Pathology Laboratory Policies and Procedures for Releasing Diagnostic Tissue for Cancer Research
- Creators
- Yao Yuan - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National InstitutesAlison L Van Dyke - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National InstitutesValentina I Petkov - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National InstitutesSarah HusseyRadim Moravec - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National InstitutesSean F Altekruse - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National InstitutesMayra Sandoval - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National InstitutesRosemary D Cress - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National InstitutesLloyd M Mueller - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National InstitutesAlan Mogi - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National InstitutesBrenda Y Hernandez - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National InstitutesFreda R Selk - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National InstitutesCharles F Lynch - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National InstitutesThomas C Tucker - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National InstitutesMary Anne Lynch - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National InstitutesChristina Lefante - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National InstitutesXiao-Cheng Wu - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National InstitutesCarol Sweeney - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National InstitutesJennifer A Doherty - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National InstitutesLynne S Penberthy - From the Surveillance Research Program, Division of Cancer Control and Population Sciences (Drs Yuan, Van Dyke, Petkov, Hussey, and Penberthy), and the Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis (Dr Moravec), National Cancer Institute, National Institutes of Health, Rockville, Maryland; the HIV/AIDS Program, National Heart, Lung, and Blood Institute, National Institutes
- Resource Type
- Journal article
- Publication Details
- Archives of pathology & laboratory medicine (1976), Vol.145(2), pp.222-226
- DOI
- 10.5858/arpa.2019-0474-OA
- PMID
- 32496836
- ISSN
- 0003-9985
- eISSN
- 1543-2165
- Language
- English
- Date published
- 06/04/2020
- Academic Unit
- Epidemiology
- Record Identifier
- 9984214813202771
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