Journal article
Pathophysiological Mechanisms of Headache in Patients With HIV
Headache, Vol.54(5), pp.946-950
05/2014
DOI: 10.1111/head.12356
PMID: 24735239
Abstract
Background
The pathophysiology of human immunodeficiency virus (HIV) is complex. The etiology of headache in the HIV population is often multifactorial, and attributing causality to specific pathophysiological mechanisms is challenging. Headaches can occur any time during the infection and may be primary (as in non‐HIV‐infected patients) or secondary (either from HIV directly or due to opportunistic disease).
Discussion
Direct HIV related headaches are due to the underlying viral pathophysiology. For example, acute meningitis can be seen during HIV‐1 seroconversion. Headaches can occur during symptomatic HIV and also after an AIDS‐defining illness. Late‐stage HIV headache can occur without any pleocytosis. A correlation between viral load and neurological symptoms including headache has been suggested. There may be similar mechanisms involving migraine, tension‐type headache, and HIV infection.
Conclusion
Secondary HIV headaches can be related to opportunistic infections, malignancy, medications used to treat HIV, and immune restoration inflammatory syndrome.
Details
- Title: Subtitle
- Pathophysiological Mechanisms of Headache in Patients With HIV
- Creators
- Shivang G Joshi - University of Massachusetts Medical SchoolTracey A Cho - Massachusetts General Hospital
- Resource Type
- Journal article
- Publication Details
- Headache, Vol.54(5), pp.946-950
- DOI
- 10.1111/head.12356
- PMID
- 24735239
- NLM abbreviation
- Headache
- ISSN
- 0017-8748
- eISSN
- 1526-4610
- Number of pages
- 5
- Language
- English
- Date published
- 05/2014
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984020615302771
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