Journal article
Pathophysiology of Adynamic Ileus
Digestive diseases and sciences, Vol.42(4), pp.731-737
04/1997
DOI: 10.1023/A:1018847626936
PMID: 9125641
Abstract
We hypothesized that the inhibitoryneurotransmitters nitric oxide (NO) and vasoactiveintestinal peptide (VIP) may play a role in thedisrupted gastrointestinal motility of endotoxemia.Strain gauge transducers on the stomach and small intestine of dogsdetermined interdigestive gastrointestinal motility.Tissue levels of NO synthase and VIP and serum levels ofnitrite/nitrate (NO2
-/NO3
-) and VIP weremeasured. Following completion of the baseline studies,dogs were given a single dose of E. colilipopolysaccharide, 200 μg/kg intravenously, and thestudies were repeated for the next three days. Following endotoxin bolus, the migrating motor complex(MMC) was delayed for two days while serum VIP wasincreased on postendotoxin day 1 and serumNO2
-/NO3
-was increased on postendotoxin day 2. There were nochanges in gut smooth muscle levels of NO synthase orVIP. We conclude that a single, sublethal dose ofendotoxin results in prolongation of the MMC withdistinct but independent increases in serum levels ofVIP and NO2
-/NO3
-
Details
- Title: Subtitle
- Pathophysiology of Adynamic Ileus
- Creators
- Joseph CullenDavid CaropresoLynda HemannMarilyn HinkhouseJeffrey ConklinKimberly Ephgrave
- Resource Type
- Journal article
- Publication Details
- Digestive diseases and sciences, Vol.42(4), pp.731-737
- Publisher
- Kluwer Academic Publishers-Plenum Publishers; New York
- DOI
- 10.1023/A:1018847626936
- PMID
- 9125641
- ISSN
- 0163-2116
- eISSN
- 1573-2568
- Language
- English
- Date published
- 04/1997
- Academic Unit
- Surgery; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984051990402771
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