Journal article
Pathophysiology of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage: A Review
Journal of the American Heart Association, Vol.10(15), pp.e021845-e021845
08/03/2021
DOI: 10.1161/JAHA.121.021845
PMCID: PMC8475656
PMID: 34325514
Abstract
Delayed cerebral ischemia is a major predictor of poor outcomes in patients who suffer subarachnoid hemorrhage. Treatment options are limited and often ineffective despite many years of investigation and clinical trials. Modern advances in basic science have produced a much more complex, multifactorial framework in which delayed cerebral ischemia is better understood and novel treatments can be developed. Leveraging this knowledge to improve outcomes, however, depends on a holistic understanding of the disease process. We conducted a review of the literature to analyze the current state of investigation into delayed cerebral ischemia with emphasis on the major themes that have emerged over the past decades. Specifically, we discuss microcirculatory dysfunction, glymphatic impairment, inflammation, and neuroelectric disruption as pathological factors in addition to the canonical focus on cerebral vasospasm. This review intends to give clinicians and researchers a summary of the foundations of delayed cerebral ischemia pathophysiology while also underscoring the interactions and interdependencies between pathological factors. Through this overview, we also highlight the advances in translational studies and potential future therapeutic opportunities.
Details
- Title: Subtitle
- Pathophysiology of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage: A Review
- Creators
- William S. Dodd - Department of Neurosurgery College of Medicine University of Florida Gainesville FLDimitri Laurent - University of FloridaAaron S. Dumont - Tulane UniversityDavid M. Hasan - University of IowaPascal M. Jabbour - Thomas Jefferson UniversityRobert M. Starke - University of MiamiKoji Hosaka - University of FloridaAdam J. Polifka - University of FloridaBrian L. Hoh - University of FloridaNohra Chalouhi - University of Florida
- Resource Type
- Journal article
- Publication Details
- Journal of the American Heart Association, Vol.10(15), pp.e021845-e021845
- DOI
- 10.1161/JAHA.121.021845
- PMID
- 34325514
- PMCID
- PMC8475656
- ISSN
- 2047-9980
- eISSN
- 2047-9980
- Language
- English
- Date published
- 08/03/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984419022802771
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