Journal article
Pathophysiology of Eosinophilic Esophagitis
Clinical reviews in allergy & immunology, Vol.55(1), pp.19-42
01/13/2018
DOI: 10.1007/s12016-017-8665-9
PMID: 29332138
Abstract
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus associated with an atopic predisposition which appears to be increasing in prevalence over the last few decades. Symptoms stem from fibrosis, swelling, and smooth muscle dysfunction. In the past two decades, the etiology of EoE has been and is continuing to be revealed. This review provides an overview of the effects of genetics, environment, and immune function including discussions that touch on microbiome, the role of diet, food allergy, and aeroallergy. The review further concentrates on the pathophysiology of the disease with particular focus on the important concepts of the molecular etiology of EoE including barrier dysfunction and allergic hypersensitivity.
Details
- Title: Subtitle
- Pathophysiology of Eosinophilic Esophagitis
- Creators
- Benjamin P Davis - Department of Internal Medicine, Division of Immunology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52246, USA. ben-davis@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Clinical reviews in allergy & immunology, Vol.55(1), pp.19-42
- DOI
- 10.1007/s12016-017-8665-9
- PMID
- 29332138
- ISSN
- 1080-0549
- eISSN
- 1559-0267
- Language
- English
- Date published
- 01/13/2018
- Academic Unit
- Stead Family Department of Pediatrics; Immunology; Internal Medicine
- Record Identifier
- 9984093371002771
Metrics
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