Journal article
Pathophysiology of pediatric heart failure
Progress in pediatric cardiology, Vol.11(3), pp.175-184
2000
DOI: 10.1016/S1058-9813(00)00048-5
PMID: 10978710
Abstract
Our understanding of the syndrome of heart failure has undergone several revisions, most importantly in the second half of the 20th century. New insights into the mechanisms of diseases offer new, challenging, controversial and sometimes counterintuitive forms of therapy. The development and progression of heart failure results from a complex interplay of hemodynamic and neurohormonal, cellular and genetic factors, rather than simply changes in cardiac function. It is because of this reason that our therapeutic focus can no longer be solely based on supply and demand models. Since the description of the pulsatile nature of the heart function and the flow of blood around a circuit by W. Harvey, numerous new paradigms have been put forward to explain the nature of heart failure. However, no single new model thus far proposed has been able to displace previous ones and successfully dictate therapy. It is the purpose of this manuscript to review the overall current understanding of the heart failure syndrome and how these new ideas may affect our therapeutic approach.
Details
- Title: Subtitle
- Pathophysiology of pediatric heart failure
- Creators
- Marcelo Auslender - Pediatric Cardiology Program, New York University Medical Center, New York, NY 10016, USA
- Resource Type
- Journal article
- Publication Details
- Progress in pediatric cardiology, Vol.11(3), pp.175-184
- DOI
- 10.1016/S1058-9813(00)00048-5
- PMID
- 10978710
- NLM abbreviation
- Prog Pediatr Cardiol
- ISSN
- 1058-9813
- eISSN
- 1558-1519
- Publisher
- Elsevier Ireland Ltd
- Language
- English
- Date published
- 2000
- Academic Unit
- Stead Family Department of Pediatrics
- Record Identifier
- 9984093481502771
Metrics
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