Journal article
Pathways Relating the Neurobiology of Attachment to Drug Addiction
Frontiers in Psychiatry, Vol.10, 737
11/08/2019
DOI: 10.3389/fpsyt.2019.00737
PMCID: PMC6857543
PMID: 31780957
Abstract
Substance use disorders constitute a significant public health problem in North America and worldwide. Specifically, substance addictions in women during pregnancy or in the postpartum period have adverse effects not only on the mother, but also on mother-infant attachment and the child’s subsequent development. Additionally, there is growing evidence suggesting that parental addiction may be transmitted intergenerationally, where the child of parents with addiction problems is more likely to experience addiction as an adult. The current review takes a developmental perspective and draws from animal and human studies to examine how compromised early experience, including insecure attachment, early abuse/neglect, and unresolved trauma, may influence the development of neurobiological pathways associated with addictions, ultimately increasing one’s susceptibility to addictions later in life. We approach this from three different levels: molecular, neuroendocrine and behavioral; and examine the oxytocin affiliation system, dopamine reward system, and glucocorticoid stress response system in this regard. Increased understanding of these underlying mechanisms may help identify key targets for early prevention efforts and inform needed intervention strategies related to both insecure attachment and addiction.
Details
- Title: Subtitle
- Pathways Relating the Neurobiology of Attachment to Drug Addiction
- Creators
- Lane Strathearn - University of Iowa, Stead Family Department of PediatricsCarol E. Mertens - University of Iowa, Stead Family Department of PediatricsLinda Mayes - Yale Child Study Center, Yale University School of Medicine, Yale University, New Haven, CT, United StatesHelena Rutherford - Yale Child Study Center, Yale University School of Medicine, Yale University, New Haven, CT, United StatesPurva Rajhans - University of IowaGuifeng Xu - University of IowaMarc N. Potenza - Yale Child Study Center, Yale University School of Medicine, Yale University, New Haven, CT, United StatesSohye Kim - Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States
- Resource Type
- Journal article
- Publication Details
- Frontiers in Psychiatry, Vol.10, 737
- Publisher
- Frontiers Media S.A
- DOI
- 10.3389/fpsyt.2019.00737
- PMID
- 31780957
- PMCID
- PMC6857543
- ISSN
- 1664-0640
- eISSN
- 1664-0640
- Copyright
- © 2019 Strathearn, Mertens, Mayes, Rutherford, Rajhans, Xu, Potenza and Kim.
- Grant note
- Funding: This work was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD065819 and R03 HD080998); National Institute on Drug Abuse (R01 DA026437, R01 DA06025, R01 DA02446 and R03 DA045289); the National Center for Responsible Gaming; the Connecticut Council on Problem Gambling; and the Connecticut Department of Mental Health and Addiction Services. The content is solely the responsibility of the authors and does not necessarily represent the official views of these institutes or the National Institutes of Health. Conflict of Interest: MP has received financial support or compensation for the following: he has consulted for RiverMend Health, Game Day Data, the Addiction Policy Forum, and Opiant Pharmaceuticals; has received research support from Mohegan Sun Casino and the National Center for Responsible Gaming; and has consulted for gambling and legal entities on issues related to addictive disorders. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
- Language
- English
- Date published
- 11/08/2019
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Developmental and Behavioral Pediatrics
- Record Identifier
- 9983763491202771
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