Journal article
Pathways for compartmentalizing protein synthesis in eukaryotic cells: the template-partitioning model
Biochemistry and cell biology, Vol.83(6), pp.687-695
12/2005
DOI: 10.1139/o05-147
PMID: 16333319
Abstract
mRNAs encoding signal sequences are translated on endoplasmic reticulum (ER) -- bound ribosomes, whereas mRNAs encoding cytosolic proteins are translated on cytosolic ribosomes. The partitioning of mRNAs to the ER occurs by positive selection; cytosolic ribosomes engaged in the translation of signal-sequence-bearing proteins are engaged by the signal-recognition particle (SRP) pathway and subsequently trafficked to the ER. Studies have demonstrated that, in addition to the SRP pathway, mRNAs encoding cytosolic proteins can also be partitioned to the ER, suggesting that RNA partitioning in the eukaryotic cell is a complex process requiring the activity of multiple RNA-partitioning pathways. In this review, key findings on this topic are discussed, and the template-partitioning model, describing a hypothetical mechanism for RNA partitioning in the eukaryotic cell, is proposed.
Details
- Title: Subtitle
- Pathways for compartmentalizing protein synthesis in eukaryotic cells: the template-partitioning model
- Creators
- Christopher V Nicchitta - Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA. c.nicchitta@celbio.duke.eduRachel S LernerSamuel B StephensRebecca D DoddBrook Pyhtila
- Resource Type
- Journal article
- Publication Details
- Biochemistry and cell biology, Vol.83(6), pp.687-695
- DOI
- 10.1139/o05-147
- PMID
- 16333319
- ISSN
- 0829-8211
- eISSN
- 1208-6002
- Grant note
- DK53058 / NIDDK NIH HHS
- Language
- English
- Date published
- 12/2005
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984094353802771
Metrics
10 Record Views