Patient Characteristics Associated with More Bother from Lower Urinary Tract Symptoms

Alice B Liu; Qian Liu; Claire C Yang; James W Griffith; Abigail R Smith; Margaret E Helmuth; H Henry Lai; Cindy L Amundsen; Bradley A Erickson; J Eric Jelovsek; Nnenaya Q Agochukwu; Margaret G Mueller; Victor P Andreev; Kevin P Weinfurt; Kimberly S Kenton; Matthew O Fraser; Anne P Cameron; Ziya Kirkali; John L Gore

doi:10.1097/JU.0000000000000324

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Patient Characteristics Associated with More Bother from Lower Urinary Tract Symptoms

Journal article

Open access

Peer reviewed

Patient Characteristics Associated with More Bother from Lower Urinary Tract Symptoms

Alice B Liu, Qian Liu, Claire C Yang, James W Griffith, Abigail R Smith, Margaret E Helmuth, H Henry Lai, Cindy L Amundsen, Bradley A Erickson, J Eric Jelovsek, …

The Journal of urology, Vol.202(3), pp.585-592

09/2019

DOI: 10.1097/JU.0000000000000324

PMCID: PMC6697227

PMID: 31063049

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Abstract

Some patients continue to have bothersome lower urinary tract symptoms despite treatment. We examined characteristics associated with bother from lower urinary tract symptoms in a prospective cohort. In this 1-year prospective, observational cohort study we obtained data on patients with lower urinary tract symptoms who were seeking care at a total of 6 tertiary care centers in the United States. Participants answered the AUA-SI (American Urological Association Symptom Index) global urinary bother question at study entry and 12 months later. Multilevel logistic and linear regression was used to identify factors associated with worsening bother and bother at 12 months, respectively. Of the 756 participants 121 (16%) had worsened lower urinary tract symptom bother during the study period. When adjusted for other variables, worsened lower urinary tract symptom bother was more likely among men who were nonwhite (OR 1.79, 95% CI 0.94-3.40) or who had diabetes (OR 1.68, 95% CI 0.86-3.27) and among women with diabetes (OR 1.77, 95% CI 0.85-3.67), prior treatment of lower urinary tract symptoms (OR 2.58, 95% CI 1.22-5.46) or a higher depression level (OR 1.29, 95% CI 1.10-1.52). Baseline factors associated with more severe bother at 12 months in men included more severe bother at baseline, nonwhite race, worse urinary frequency and incontinence, and higher levels of stress (p <0.05). Among women more severe bother at baseline, urinary urgency and frequency, and worse physical function were associated with more severe bother at 12 months. Urinary symptom severity at baseline, race, depression and psychological stress were associated with the bother of lower urinary tract symptoms in a prospective cohort of men and women treated at tertiary care facilities. These findings may inform the clinical care of patients with bothersome lower urinary tract symptoms and direct providers to better prognosticate for patients with challenging lower urinary tract symptoms cases.

Severity of Illness Index

Prospective Studies

Lower Urinary Tract Symptoms - psychology

Humans

Middle Aged

Male

Self Report - statistics & numerical data

Lower Urinary Tract Symptoms - therapy

Stress, Psychological - psychology

Stress, Psychological - diagnosis

Lower Urinary Tract Symptoms - diagnosis

Sex Factors

Adult

Female

Aged

Details

Title: Subtitle: Patient Characteristics Associated with More Bother from Lower Urinary Tract Symptoms
Creators: Alice B Liu - Department of Urology, University of Washington, Seattle, Washington
Qian Liu - Arbor Research Collaborative for Health, Ann Arbor, Michigan
Claire C Yang - Department of Urology, University of Washington, Seattle, Washington
James W Griffith - Northwestern University Feinberg School of Medicine, Chicago, Illinois
Abigail R Smith - Arbor Research Collaborative for Health, Ann Arbor, Michigan
Margaret E Helmuth - Arbor Research Collaborative for Health, Ann Arbor, Michigan
H Henry Lai - Washington University School of Medicine, St Louis, Missouri
Cindy L Amundsen - Duke University Medical Center, Durham, North Carolina
Bradley A Erickson - Department of Urology, University of Iowa, Iowa City, Iowa
J Eric Jelovsek - Duke University Medical Center, Durham, North Carolina
Nnenaya Q Agochukwu - University of Michigan, Ann Arbor, Michigan
Margaret G Mueller - Northwestern University Feinberg School of Medicine, Chicago, Illinois
Victor P Andreev - Arbor Research Collaborative for Health, Ann Arbor, Michigan
Kevin P Weinfurt - Duke University Medical Center, Durham, North Carolina
Kimberly S Kenton - Northwestern University Feinberg School of Medicine, Chicago, Illinois
Matthew O Fraser - Duke University Medical Center, Durham, North Carolina
Anne P Cameron - University of Michigan, Ann Arbor, Michigan
Ziya Kirkali - National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland
John L Gore - Department of Urology, University of Washington, Seattle, Washington
Resource Type: Journal article
Publication Details: The Journal of urology, Vol.202(3), pp.585-592
DOI: 10.1097/JU.0000000000000324
PMID: 31063049
PMCID: PMC6697227
NLM abbreviation: J Urol
ISSN: 0022-5347
eISSN: 1527-3792
Publisher: United States
Grant note: U01 DK100017 / NIDDK NIH HHS U01 DK100011 / NIDDK NIH HHS U01 DK097779 / NIDDK NIH HHS U01 DK097780 / NIDDK NIH HHS U01 DK099879 / NIDDK NIH HHS U01 DK097776 / NIDDK NIH HHS U01 DK097772 / NIDDK NIH HHS U01 DK099932 / NIDDK NIH HHS
Language: English
Date published: 09/2019
Academic Unit: Urology
Record Identifier: 9984051588302771

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