Patient and tumor characteristics associated with primary tumor resection in women with Stage IV breast cancer: analysis of 1988-2003 SEER data

Jennifer Gnerlich; Jeffrey M Dueker; Donna B Jeffe; Anjali D Deshpande; Samantha Thompson; Julie A Margenthaler

doi:10.1111/j.1524-4741.2008.00644.x

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Patient and tumor characteristics associated with primary tumor resection in women with Stage IV breast cancer: analysis of 1988-2003 SEER data

Journal article

Peer reviewed

Patient and tumor characteristics associated with primary tumor resection in women with Stage IV breast cancer: analysis of 1988-2003 SEER data

Jennifer Gnerlich, Jeffrey M Dueker, Donna B Jeffe, Anjali D Deshpande, Samantha Thompson and Julie A Margenthaler

The breast journal, Vol.14(6), pp.538-542

11/2008

DOI: 10.1111/j.1524-4741.2008.00644.x

PMID: 19000055

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Abstract

Surgery is the cornerstone of treatment for women with nonmetastatic breast cancer. In contrast, standard treatment for patients with Stage IV disease includes chemotherapy and radiation, with surgery usually reserved for local tumor-related complications. Little is known about the predictive factors associated with primary tumor resection for Stage IV breast cancer. We conducted a retrospective, population-based, case-control study using the 1988-2003 Surveillance Epidemiology and End Results (SEER) data. Using multiple logistic regression, we identified patient and tumor characteristics from among SEER region, age at diagnosis, year of diagnosis, marital status, race, Hispanic ethnicity, tumor grade, and size that were associated with surgical resection of the primary breast tumor (compared with no surgical resection) among women with stage IV breast cancer. Adjusted odds ratios and 95% confidence intervals are reported. Of 10,017 patients, 4,836 (48%) underwent surgical resection of the primary breast tumor. Patients in the Northeast and Midwest and patients presenting with two or more primary breast tumors were more likely to have surgical resection. Patients who were older, diagnosed after 1992, unmarried, black, and whose tumors were >5 cm, inflammatory, of unknown size, indeterminate grade, or unknown progesterone status were less likely to have had surgical resection of the primary tumor. Several patient and tumor characteristics were significantly associated with surgical resection of the primary breast tumor in Stage IV disease. Further study of the surgery decision-making process is recommended.

Breast Neoplasms - surgery

Inflammation - pathology

United States - epidemiology

Humans

Middle Aged

Marital Status

Case-Control Studies

Young Adult

Receptors, Progesterone - analysis

Ethnic Groups

Breast Neoplasms - pathology

Adolescent

Aged, 80 and over

Adult

Female

Aged

Retrospective Studies

Continental Population Groups

Neoplasm Staging

Child

Breast Neoplasms - epidemiology

Details

Title: Subtitle: Patient and tumor characteristics associated with primary tumor resection in women with Stage IV breast cancer: analysis of 1988-2003 SEER data
Creators: Jennifer Gnerlich - Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
Jeffrey M Dueker
Donna B Jeffe
Anjali D Deshpande
Samantha Thompson
Julie A Margenthaler
Resource Type: Journal article
Publication Details: The breast journal, Vol.14(6), pp.538-542
Publisher: United States
DOI: 10.1111/j.1524-4741.2008.00644.x
PMID: 19000055
ISSN: 1075-122X
eISSN: 1524-4741
Language: English
Date published: 11/2008
Academic Unit: Epidemiology
Record Identifier: 9983995137302771

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