Journal article
Patient and tumor characteristics of colon cancers with microsatellite instability : A population-based study
Cancer epidemiology, biomarkers & prevention, Vol.9(6), pp.539-544
2000
PMID: 10868685
Abstract
Molecular screening for microsatellite instability (MSI) in colon cancers has been proposed to identify individuals with hereditary nonpolyposis colorectal cancer. To date, most reports of MSI in colorectal cancer have been based on studies of clinical case series or high-risk families. We examined the proportion of incident colon cancers in the general population that exhibit MSI by patient and tumor characteristics. We interviewed 201 colon cancer cases ascertained by the New Mexico Tumor Registry in the metropolitan Albuquerque area for demographic information, lifestyle factors, medical history, and family cancer history. Paired normal and tumor tissue specimens were obtained for each case. Three microsatellite markers were used; instability was defined as observed alteration at two or more loci. Overall, 37 of 201 (18%) colon cancers exhibited instability. MSI was more common among cases >70 years (26%) and most common among cases >80 years (38%). MSI was significantly associated with tumors in the proximal colon and with later stage and poor differentiation among cases >70 years. MSI was not associated with a history of polyps. Family history of colorectal cancer was associated with MSI only among cases <50 years. When all factors were analyzed jointly in a regression model, proximal subsite and poor differentiation remained significantly associated with MSI. One patient, whose tumor exhibited MSI, fulfilled the Amsterdam Criteria for hereditary nonpolyposis colorectal cancer. Our study provides a population-based estimate of MSI in colon tumors and a representative estimate of the proportion of colorectal cancer patients in the general population who consent to be interviewed for family cancer history and to have biological samples analyzed.
Details
- Title: Subtitle
- Patient and tumor characteristics of colon cancers with microsatellite instability : A population-based study
- Creators
- Ann Chao - New Mexico Tumor Registry, University of New Mexico, Albuquerque, New Mexico 87131, United StatesFrank Gilliland - Department of Preventive Medicine, University of Southem California, Los Angeles, California 90033, United StatesCheryl Willman - Center for Molecular and Cellular Diagnostics, University of New Mexico, Albuquerque, New Mexico 87131, United StatesNancy Joste - Department of Pathology, University of New Mexico, Albuquerque, New Mexico 87131, United StatesI-Ming Chen - Center for Molecular and Cellular Diagnostics, University of New Mexico, Albuquerque, New Mexico 87131, United StatesNoell Stone - New Mexico Tumor Registry, University of New Mexico, Albuquerque, New Mexico 87131, United StatesJennifer Ruschulte - Center for Molecular and Cellular Diagnostics, University of New Mexico, Albuquerque, New Mexico 87131, United StatesDavid Viswanatha - Center for Molecular and Cellular Diagnostics, University of New Mexico, Albuquerque, New Mexico 87131, United StatesPaul Duncan - Saint Joseph Healthcare Systems, Albuquerque, New Mexico 87125, United StatesRichard Ming - Lovelace Medical Center, Albuquerque, New Mexico 87125, United StatesRichard Hoffman - Department of Veterans Affairs Medical Center, Albuquerque, New Mexico 87125, United StatesElliott Foucar - Presbyterian Healthcare Services, Albuquerque, New Mexico 87125, United StatesCharles Key - New Mexico Tumor Registry, University of New Mexico, Albuquerque, New Mexico 87131, United States
- Resource Type
- Journal article
- Publication Details
- Cancer epidemiology, biomarkers & prevention, Vol.9(6), pp.539-544
- Publisher
- American Association for Cancer Research
- PMID
- 10868685
- ISSN
- 1055-9965
- eISSN
- 1538-7755
- Language
- English
- Date published
- 2000
- Academic Unit
- Epidemiology; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984094878302771
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