Patient demographics, clinicopathologic features, and outcomes in wild-type gastrointestinal stromal tumor: a national cohort analysis

Tahsin M Khan; Emily A Verbus; Alexander J Rossi; Jonathan M Hernandez; Jeremy L Davis; Brian A Coakley; Andrew M Blakely

doi:10.1038/s41598-022-09745-1

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Patient demographics, clinicopathologic features, and outcomes in wild-type gastrointestinal stromal tumor: a national cohort analysis

Journal article

Open access

Peer reviewed

Patient demographics, clinicopathologic features, and outcomes in wild-type gastrointestinal stromal tumor: a national cohort analysis

Tahsin M Khan, Emily A Verbus, Alexander J Rossi, Jonathan M Hernandez, Jeremy L Davis, Brian A Coakley and Andrew M Blakely

Scientific reports, Vol.12(1), pp.5774-8

04/06/2022

DOI: 10.1038/s41598-022-09745-1

PMCID: PMC8987058

PMID: 35388076

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Abstract

Wild-type KIT and PDGFRA gastrointestinal stromal tumors (GIST) are rare tumors with limited treatment options. We sought to determine the clinicopathologic features of wild-type GIST and identify factors that influence overall survival (OS) using a large national database. Retrospective evaluation of patients with wild-type GIST in the National Cancer Database (NCDB) was performed. Demographic, clinicopathologic, and treatment data were analyzed. Features associated with OS were investigated using Kaplan-Meier analysis and Cox proportional hazards model. 244 patients with median diagnosis age of 59 years (95% CI 57-63) were identified. The stomach was the most common primary site (57%) followed by the small intestine (35%). Surgical resection was performed on 85% of patients and 53% of patients received systemic therapy. Factors associated with decreased OS on multivariable analysis included small intestine primary (HR 2.72, 95% CI 1.13-6.69, P = 0.026) and > 5 mitoses per 50 HPF (HR 4.77, 95% CI 1.86-13.2, P = 0.001). Wild-type GISTs may be identified in older patients, with most arising in the stomach and small bowel. Surgery remains the principal treatment modality. Small intestine primary site and high mitotic count were associated with abbreviated OS.

Aged

Demography

Gastrointestinal Stromal Tumors - epidemiology

Gastrointestinal Stromal Tumors - genetics

Gastrointestinal Stromal Tumors - surgery

Humans

Intestine, Small - pathology

Intestine, Small - surgery

Kaplan-Meier Estimate

Middle Aged

Retrospective Studies

Details

Title: Subtitle: Patient demographics, clinicopathologic features, and outcomes in wild-type gastrointestinal stromal tumor: a national cohort analysis
Creators: Tahsin M Khan - Mount Sinai Hospital
Emily A Verbus - National Cancer Institute
Alexander J Rossi - National Cancer Institute
Jonathan M Hernandez - National Cancer Institute
Jeremy L Davis - National Cancer Institute
Brian A Coakley - Mount Sinai Hospital
Andrew M Blakely - National Institutes of Health
Resource Type: Journal article
Publication Details: Scientific reports, Vol.12(1), pp.5774-8
DOI: 10.1038/s41598-022-09745-1
PMID: 35388076
PMCID: PMC8987058
NLM abbreviation: Sci Rep
ISSN: 2045-2322
eISSN: 2045-2322
Language: English
Date published: 04/06/2022
Academic Unit: Surgery
Record Identifier: 9985224416502771

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