Journal article
Patient-reported outcomes of blue-light flexible cystoscopy with hexaminolevulinate in the surveillance of bladder cancer: results from a prospective multicentre study
BJU international, Vol.123(1), pp.35-41
01/2019
DOI: 10.1111/bju.14481
PMID: 29979488
Abstract
To evaluate blue-light flexible cystoscopy (BLFC) with hexaminolevulinate in the office surveillance of patients with non-muscle-invasive bladder cancer with a high risk of recurrence by assessing its impact on pain, anxiety, subjective value of the test and patient willingness to pay.
A prospective, multicentre, phase III study was conducted during which the Patient-Reported Outcomes Measurement Information System (PROMIS) Anxiety, Pain and 'Was It Worth It' questionnaires were administered at baseline, after surveillance with BLFC and after resection for those referred to the operating room. Comparisons of scores were performed between groups.
A total of 304 patients were enrolled, of whom 103 were referred for surgical examination. Of these, 63 were found to have histologically confirmed malignancy. Pain levels were low throughout the study. Anxiety levels decreased after BLFC (∆ = -2.6), with a greater decrease among those with negative pathology results (P = 0.051). No differences in anxiety were noted based on gender, BLFC results, or test performance (true-positive/false-positive). Most patients found BLFC 'worthwhile' (94%), would 'do it again' (94%) and 'would recommend it to others' (91%), with no differences based on BLFC results or test performance. Most patients undergoing BLFC (76%) were willing to pay out of pocket.
Anxiety decreased after BLFC in patients with negative pathology, including patients with false-positive results. Most of the patients undergoing BLFC were willing to pay out of pocket, found the procedure worthwhile and would recommend it to others, irrespective of whether they had a positive BLFC result or whether this was false-positive after surgery.
Details
- Title: Subtitle
- Patient-reported outcomes of blue-light flexible cystoscopy with hexaminolevulinate in the surveillance of bladder cancer: results from a prospective multicentre study
- Creators
- Angela B Smith - University of North Carolina at Chapel HillSiamak Daneshmand - University of Southern California, Los Angeles, CA, USASanjay Patel - University of OklahomaKamal Pohar - Ohio State University, Columbus, OH, USAEdouard Trabulsi - Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USAMichael Woods - University of North Carolina, Chapel Hill, NC, USATracy Downs - University of Wisconsin, Madison, WI, USAWilliam Huang - New York University School of Medicine, New York, NY, USAJennifer Taylor - ME DeBakey VA Medical Center, Houston, TX, USAJeffrey Jones - ME DeBakey VA Medical Center, Houston, TX, USAMichael O'Donnell - University of Iowa, Iowa City, IA, USATrinity Bivalacqua - Johns Hopkins University, Baltimore, MD, USAJoel DeCastro - Columbia University Medical Center, New York, NY, USAGary Steinberg - University of Chicago, Chicago, IL, USAAshish Kamat - MD Anderson Cancer Center, University of Texas, Houston, TX, USAMatthew Resnick - Vanderbilt University, Nashville, TX, USABadrinath Konety - University of Minnesota, Minneapolis, MN, USAMark Schoenberg - Montefiore Medical Center, The Albert Einstein College of Medicine, Bronx, NY, USAJ Stephen Jones - Cleveland Clinic, Cleveland, OH, USAYair Lotan - UT Southwestern Medical Center, Dallas, TX, USA
- Resource Type
- Journal article
- Publication Details
- BJU international, Vol.123(1), pp.35-41
- DOI
- 10.1111/bju.14481
- PMID
- 29979488
- NLM abbreviation
- BJU Int
- ISSN
- 1464-4096
- eISSN
- 1464-410X
- Publisher
- England
- Grant note
- P30 CA086862 / NCI NIH HHS
- Language
- English
- Date published
- 01/2019
- Academic Unit
- Urology
- Record Identifier
- 9984051743402771
Metrics
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